{"id":"W2998920613","doi":"10.1007/s40263-020-00700-0","title":"Diroximel Fumarate Demonstrates an Improved Gastrointestinal Tolerability Profile Compared with Dimethyl Fumarate in Patients with Relapsing–Remitting Multiple Sclerosis: Results from the Randomized, Double-Blind, Phase III EVOLVE-MS-2 Study","year":2020,"lang":"en","type":"article","venue":"CNS Drugs","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Biogen","keywords":"Tolerability; Dimethyl fumarate; Medicine; Adverse effect; Nausea; Internal medicine; Gastroenterology; Multiple sclerosis; Diarrhea; Abdominal pain; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001833347,0.0009923801,0.002577571,0.0002840509,0.0002580057,0.0005902453,0.0005236751,0.0008254506,0.002491503],"category_scores_gemma":[0.001149622,0.0004437854,0.001437775,0.0003041206,0.0005353148,0.0007377744,0.0002459286,0.001517076,0.0003840626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004244375,"about_ca_system_score_gemma":0.0004992806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004239743,"about_ca_topic_score_gemma":0.001272768,"domain_scores_codex":[0.9994774,0.0002843648,0.00004394729,0.00007670328,0.00005566028,0.00006190267],"domain_scores_gemma":[0.9991632,0.000219738,0.0002674822,0.00006369931,0.00005918783,0.0002267147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8748635,0.01747837,0.003794574,0.0009120294,0.00186972,0.0001427609,0.0001487242,0.0006189919,0.04615328,0.00005707293,0.0005611348,0.0533997],"study_design_scores_gemma":[0.4426227,0.5311164,0.01848608,0.00002881528,0.001020551,0.0002348888,0.00004294941,0.0007281423,0.004803488,0.00004636797,0.0008409569,0.00002862786],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967811,0.00206387,0.0002096253,0.0001004455,0.0000403782,0.0002413187,0.000175786,0.00004053979,0.0003469102],"genre_scores_gemma":[0.9969631,0.0009648268,0.0005883818,0.0002349301,0.0001189566,0.0002134093,0.0003898164,0.00001279881,0.0005138328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002577571,"threshold_uncertainty_score":0.009695768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07551401859164208,"score_gpt":0.3057251555602757,"score_spread":0.2302111369686336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}