{"id":"W2998937323","doi":"10.1038/s41596-019-0249-0","title":"Activation and expansion of human T cells using artificial antigen-presenting cell scaffolds","year":2020,"lang":"en","type":"article","venue":"Nature Protocols","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; U.S. Food and Drug Administration; National Institutes of Health; Government of Canada; U.S. Department of Health and Human Services","keywords":"Cell biology; Antigen-presenting cell; T cell; Antigen; Chimeric antigen receptor; Chemistry; Cell; Cell culture; Cell therapy; Ex vivo; Biology; Molecular biology; In vitro; Stem cell; Immunology; Biochemistry; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002541212,0.0001340653,0.000282376,0.0001085936,0.0001019591,0.00003642706,0.0000929395,0.0002954103,0.0002370328],"category_scores_gemma":[0.00005834326,0.0001215872,0.00007185822,0.0003373486,0.00006272853,0.0001048618,0.00009504679,0.0004381273,0.000003111838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003508909,"about_ca_system_score_gemma":0.00009393815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001762486,"about_ca_topic_score_gemma":8.976095e-7,"domain_scores_codex":[0.9986194,0.00006346525,0.0002778543,0.0003053981,0.0005101449,0.0002237118],"domain_scores_gemma":[0.9992911,0.00004607165,0.0001375568,0.0002097977,0.0001803747,0.0001351514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004096057,0.00008307621,0.003074605,0.0005391128,0.00001477495,0.000008955675,0.0003939805,0.000005942581,0.9916567,0.00007532006,0.0001081787,0.00362977],"study_design_scores_gemma":[0.0009816214,0.0003390095,0.001503966,0.0002095877,0.00001161612,0.000002759978,0.00009505091,0.001178967,0.9935923,0.0001084594,0.001876613,0.0001000957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9548348,0.00002211783,0.0001395772,0.000235146,0.00001872264,0.04343395,0.000002929253,0.00003854292,0.001274216],"genre_scores_gemma":[0.9957104,0.000002060612,0.001313247,0.0001822848,0.0003790601,0.002277448,0.000008387181,0.00003356708,0.00009358011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0411565,"threshold_uncertainty_score":0.4958182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07538587506011594,"score_gpt":0.4011215187859922,"score_spread":0.3257356437258762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}