{"id":"W2999011345","doi":"10.1038/s41598-020-57530-9","title":"Reduced Expression of Genes Regulating Cohesion Induces Chromosome Instability that May Promote Cancer and Impact Patient Outcomes","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; Research Institute in Oncology and Hematology; University of Manitoba","funders":"Canadian Institutes of Health Research; University of Bristol; Strong; Natural Sciences and Engineering Research Council of Canada; CancerCare Manitoba Foundation","keywords":"Establishment of sister chromatid cohesion; Chromosome instability; Genome instability; Biology; Gene silencing; Genetics; Gene; Sister chromatids; Cancer; Phenotype; Cancer research; Chromosome; Cancer cell; Mitosis; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002511245,0.0001369874,0.0001995496,0.00002934325,0.0001214393,0.00006448074,0.00007288104,0.00008264887,0.0000210231],"category_scores_gemma":[0.0002364343,0.0001061486,0.00008378894,0.0001069232,0.0001509374,0.000009541243,0.0002172454,0.00004761578,2.418134e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002337648,"about_ca_system_score_gemma":0.0001969474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008339386,"about_ca_topic_score_gemma":0.00001703648,"domain_scores_codex":[0.9986324,0.00002681699,0.0003453071,0.0005991719,0.000225228,0.0001711155],"domain_scores_gemma":[0.9989579,0.00001216945,0.0003558271,0.000421221,0.0001142691,0.0001386131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002342606,0.00002881487,0.1097291,0.00003506214,0.000011585,0.000006005741,0.0003010868,0.000124697,0.8823848,6.136283e-7,0.0005943182,0.006760474],"study_design_scores_gemma":[0.0001214097,0.0001243354,0.02194828,0.00003808849,0.00001178616,0.000009828545,0.00007756068,0.00003069791,0.97471,0.00008700616,0.002713862,0.0001271733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973189,0.001296341,0.00001114249,0.0002142357,0.0007833198,0.0002929067,0.00002884028,0.000008335473,0.00004599831],"genre_scores_gemma":[0.9993627,0.00007370416,0.0003457971,0.00004125555,0.00005219248,0.00001662692,0.0000647335,0.00001276936,0.00003020331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09232511,"threshold_uncertainty_score":0.4328614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0239666158355145,"score_gpt":0.283943095543672,"score_spread":0.2599764797081575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}