{"id":"W2999036644","doi":"10.1016/j.toxlet.2020.01.013","title":"Pharmacokinetics of Three Oximes in a Guinea Pig Model and Efficacy of Combined Oxime Therapy","year":2020,"lang":"en","type":"article","venue":"Toxicology Letters","topic":"Pesticide Exposure and Toxicity","field":"Agricultural and Biological Sciences","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Defence Research and Development Canada","funders":"","keywords":"Oxime; Pralidoxime; Pharmacology; Acetylcholinesterase; Pharmacokinetics; Nerve agent; Atropine; Chemistry; Cholinesterase; Sarin; Anesthesia; Medicine; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001078238,0.0001082285,0.0002767895,0.0000135427,0.00002304515,0.000003991064,0.0001794289,0.00007319906,0.0001181049],"category_scores_gemma":[0.00004618117,0.00004892937,0.00004810391,0.000184525,0.000167197,0.00003517802,0.00006184237,0.0001083759,0.00000220678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004812728,"about_ca_system_score_gemma":0.000005256326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000394566,"about_ca_topic_score_gemma":0.00005197337,"domain_scores_codex":[0.9992169,0.00005740184,0.0002592508,0.0001864071,0.0000912605,0.0001888002],"domain_scores_gemma":[0.9995505,0.0002288919,0.0001018482,0.00003676151,0.00001832357,0.00006364065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002335672,0.0001366329,0.02369294,0.000005822244,0.00001864939,0.000005104535,0.0001224652,0.0003603674,0.9696448,0.0001201658,0.0004560275,0.005203405],"study_design_scores_gemma":[0.00306336,0.001825468,0.7628717,0.00001458506,0.00002927148,0.000003410887,0.00002866923,0.01275873,0.2181282,0.0007203481,0.000287433,0.0002688178],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843023,0.0001377245,0.00003137007,0.01517635,0.00002254251,0.0001794221,0.00001523021,0.00001845364,0.0001166054],"genre_scores_gemma":[0.9943709,0.00003973923,0.0002258928,0.005302896,0.0000453624,0.000004708657,0.00000596414,9.674329e-7,0.000003541207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7515166,"threshold_uncertainty_score":0.1995282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04273777992223805,"score_gpt":0.2466611812257564,"score_spread":0.2039234013035183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}