{"id":"W2999039360","doi":"10.1038/s41467-019-14184-0","title":"Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Congressionally Directed Medical Research Programs; Science and Engineering Research Board; The Wellcome Trust DBT India Alliance; University Grants Commission; Department of Science and Technology, Ministry of Science and Technology, India; U.S. Department of Defense; Department of Biotechnology, Ministry of Science and Technology, India; Sleep Research Society Foundation; Wellcome Trust","keywords":"Downregulation and upregulation; Prostate cancer; Cancer research; Transdifferentiation; Androgen receptor; Repressor; Biology; Androgen deprivation therapy; Carcinogenesis; Corepressor; Endocrinology; Cancer; Internal medicine; Medicine; Cell biology; Gene expression; Genetics; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005012938,0.000143697,0.000167967,0.0001462471,0.0001439753,0.0002390937,0.00008936706,0.0000833627,0.00130353],"category_scores_gemma":[0.00005831345,0.00007361822,0.0001407672,0.0001081017,0.0001337675,0.00008878233,0.0001749961,0.0003602348,0.0001745508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001886132,"about_ca_system_score_gemma":0.0001699957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007333761,"about_ca_topic_score_gemma":0.002671776,"domain_scores_codex":[0.9999343,0.000008774343,0.000004173251,0.00001017985,0.00001903351,0.0000234539],"domain_scores_gemma":[0.9999523,0.00000672016,0.000009073699,0.000005136301,0.00000357958,0.00002323822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000199894,0.00004029681,0.0006755351,0.00005556008,0.000007180254,0.00007653995,0.00001574897,0.00005953732,0.995704,0.00007425924,0.0001265396,0.002964937],"study_design_scores_gemma":[0.00003526375,0.001586341,0.08937409,0.00001224836,0.00004266495,0.0007819237,0.0001252641,0.000781441,0.898845,0.0001237394,0.00827432,0.00001764298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947101,0.002932502,0.0003148542,0.00009662635,0.00002940059,0.000009166305,0.0002209982,0.00005997641,0.001626465],"genre_scores_gemma":[0.9979516,0.0007654036,0.0001345457,0.00003153347,0.000005404374,0.000005580588,0.0001719684,0.000004802695,0.0009292492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00130353,"threshold_uncertainty_score":0.004360735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03018527477136436,"score_gpt":0.3266954629762737,"score_spread":0.2965101882049094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}