{"id":"W2999113451","doi":"10.1016/j.clinbiochem.2020.01.003","title":"Circulating PCSK9 is associated with liver biomarkers and hepatic steatosis","year":2020,"lang":"en","type":"article","venue":"Clinical Biochemistry","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Heart Institute; Université de Montréal; Montreal Clinical Research Institute","funders":"Københavns Universitet; Fondation Leducq; University of Cambridge; Novo Nordisk Canada; Institut de Recherche Clinique De Montréal; National Institute for Health and Care Research; FURTHERMORE grants in publishing; Ionis Pharmaceuticals; Amgen; Boehringer Ingelheim; Regeneron Pharmaceuticals; Novartis; Center for Global Health; Danish International Development Agency; Pfizer; Rådet for Udviklingsforskning; NIHR Bristol Biomedical Research Centre; Eli Lilly and Company; Valeant Pharmaceuticals International; NIHR Cambridge Biomedical Research Centre; Amgen Canada; Sanofi; Merck","keywords":"Steatosis; Internal medicine; Medicine; PCSK9; Endocrinology; Fatty liver; Metabolic syndrome; Bilirubin; Albumin; Cirrhosis; Alkaline phosphatase; Gastroenterology; Cholesterol; Biology; Disease; Obesity; Lipoprotein; LDL receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000462212,0.0001405431,0.0004550843,0.000008907846,0.0000613874,0.00001713337,0.00005576542,0.0002189869,0.00007948072],"category_scores_gemma":[0.001128802,0.0001099169,0.0002110918,0.0001747905,0.0001538847,0.00002118282,0.00005347562,0.0002891523,0.00001161094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003325528,"about_ca_system_score_gemma":0.0001468902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000213941,"about_ca_topic_score_gemma":6.075023e-7,"domain_scores_codex":[0.9986323,0.00005553095,0.0003689676,0.0004451819,0.0002946669,0.0002033272],"domain_scores_gemma":[0.9988983,0.0001369622,0.0001131094,0.0003060612,0.00008316287,0.0004623494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000735448,0.0005698587,0.8340662,0.002459456,0.005311483,0.001291896,0.0005008444,6.111292e-7,0.02310365,0.000005669799,0.004930952,0.127024],"study_design_scores_gemma":[0.03361203,0.004772597,0.6963224,0.004578476,0.006240799,0.0009870927,0.001754366,0.01202289,0.2291758,0.00005137789,0.007978675,0.002503439],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953646,0.001199655,0.00005967277,0.002082526,0.00002233295,0.0002192803,0.00001254654,0.00006705444,0.0009723165],"genre_scores_gemma":[0.9948218,0.000155451,0.0004206808,0.004212227,0.0002670668,0.000007931165,0.0000303294,0.0000213098,0.00006320708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2060722,"threshold_uncertainty_score":0.4482282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04405863842136026,"score_gpt":0.3047175588715545,"score_spread":0.2606589204501942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}