{"id":"W2999113451","doi":"10.1016/j.clinbiochem.2020.01.003","title":"Circulating PCSK9 is associated with liver biomarkers and hepatic steatosis","year":2020,"lang":"en","type":"article","venue":"Clinical Biochemistry","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Heart Institute; Université de Montréal; Montreal Clinical Research Institute","funders":"Københavns Universitet; Fondation Leducq; University of Cambridge; Novo Nordisk Canada; Institut de Recherche Clinique De Montréal; National Institute for Health and Care Research; FURTHERMORE grants in publishing; Ionis Pharmaceuticals; Amgen; Boehringer Ingelheim; Regeneron Pharmaceuticals; Novartis; Center for Global Health; Danish International Development Agency; Pfizer; Rådet for Udviklingsforskning; NIHR Bristol Biomedical Research Centre; Eli Lilly and Company; Valeant Pharmaceuticals International; NIHR Cambridge Biomedical Research Centre; Amgen Canada; Sanofi; Merck","keywords":"Steatosis; Internal medicine; Medicine; PCSK9; Endocrinology; Fatty liver; Metabolic syndrome; Bilirubin; Albumin; Cirrhosis; Alkaline phosphatase; Gastroenterology; Cholesterol; Biology; Disease; Obesity; Lipoprotein; LDL receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004367053,0.0006599224,0.0007212713,0.0009571493,0.0004032537,0.001169818,0.0003650535,0.0008416886,0.003103163],"category_scores_gemma":[0.002422074,0.0004504028,0.0007484297,0.001358277,0.000342942,0.0004499547,0.0005121166,0.001154524,0.0005526193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002819994,"about_ca_system_score_gemma":0.0002472944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001543249,"about_ca_topic_score_gemma":0.001466276,"domain_scores_codex":[0.9995456,0.0001161018,0.00007585534,0.0001121248,0.00007697879,0.00007322055],"domain_scores_gemma":[0.9975745,0.0005037404,0.001197314,0.0001982805,0.0001916259,0.0003346639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002093954,0.000100215,0.9873213,0.00005510688,0.0004382546,0.0003414141,0.00005871693,0.00009000659,0.003517566,0.00006951296,0.0002161066,0.005697911],"study_design_scores_gemma":[0.00001794466,0.0001322129,0.997606,0.00001132558,0.0001392726,0.0007440131,0.00005780432,0.0003943217,0.0005147417,0.0001423888,0.0002304031,0.000009598324],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959513,0.001456737,0.0004789564,0.0002304113,0.00005717662,0.000009772424,0.0004893928,0.00003673836,0.001289534],"genre_scores_gemma":[0.9979163,0.0002801026,0.0004029222,0.00006658029,0.00006925626,0.00000600736,0.0003975026,0.000008266953,0.0008531873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003103163,"threshold_uncertainty_score":0.0103811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04405863842136026,"score_gpt":0.3047175588715545,"score_spread":0.2606589204501942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}