{"id":"W2999119259","doi":"10.1093/carcin/bgz205","title":"Epidermal ROCK2 induces AKT1/GSK3β/β-catenin, NFκB and dermal tenascin C; but enhanced differentiation and p53/p21 inhibit papilloma","year":2020,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University; MaRS","funders":"Cancer Research UK","keywords":"Keratin 5; Catenin; Keratinocyte; Cancer research; Carcinogenesis; Biology; Tenascin; Tenascin C; Wound healing; Cell biology; Chemistry; Immunology; Cancer; Wnt signaling pathway; Signal transduction; Extracellular matrix; Immunohistochemistry; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116211,0.0005594118,0.0001868588,0.0004042701,0.0001938079,0.0002994376,0.0001639006,0.0002781354,0.003746406],"category_scores_gemma":[0.0000676688,0.000225481,0.000383753,0.0001179372,0.0002742878,0.0002157518,0.0002452839,0.0007811908,0.0008028371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002193992,"about_ca_system_score_gemma":0.0001825737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004899257,"about_ca_topic_score_gemma":0.00109168,"domain_scores_codex":[0.9998217,0.0000182227,0.00001474307,0.00004153572,0.00005610802,0.00004763047],"domain_scores_gemma":[0.9998411,0.00001154643,0.00005218409,0.00002309365,0.00001276495,0.00005929587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005353628,0.00001644858,0.00009745558,0.0000160545,0.000002180545,0.00003742731,0.000007127953,0.00001277641,0.9993868,0.00006118981,0.00001848002,0.0002905953],"study_design_scores_gemma":[0.00001051068,0.00012599,0.002684759,0.000003433341,0.000009769529,0.0002366205,0.00002235956,0.0003040151,0.9952576,0.00003036197,0.001312484,0.000002122807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937028,0.0004449225,0.002291712,0.000083706,0.00002777032,0.00003077537,0.0006270448,0.0002247023,0.00256661],"genre_scores_gemma":[0.985494,0.0003151352,0.001394444,0.00003380041,0.000006873163,0.0000398002,0.0007919235,0.00005124761,0.0118727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003746406,"threshold_uncertainty_score":0.01253301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02138624430102764,"score_gpt":0.2228420013650771,"score_spread":0.2014557570640495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}