{"id":"W2999119259","doi":"10.1093/carcin/bgz205","title":"Epidermal ROCK2 induces AKT1/GSK3β/β-catenin, NFκB and dermal tenascin C; but enhanced differentiation and p53/p21 inhibit papilloma","year":2020,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University; MaRS","funders":"Cancer Research UK","keywords":"Keratin 5; Catenin; Keratinocyte; Cancer research; Carcinogenesis; Biology; Tenascin; Tenascin C; Wound healing; Cell biology; Chemistry; Immunology; Cancer; Wnt signaling pathway; Signal transduction; Extracellular matrix; Immunohistochemistry; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009723937,0.0002921058,0.0003189311,0.00004752871,0.0002215771,0.00004820602,0.0001222247,0.0001945903,0.00001057647],"category_scores_gemma":[0.0002006161,0.000270301,0.00007930457,0.000112807,0.0001342768,0.00001102709,0.0002969961,0.00009324228,0.000007774124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001116486,"about_ca_system_score_gemma":0.00004682076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002820305,"about_ca_topic_score_gemma":0.00001819555,"domain_scores_codex":[0.9984533,0.00009709739,0.0002958621,0.0006484789,0.0001573683,0.0003478687],"domain_scores_gemma":[0.999332,0.00003002916,0.0001096032,0.000184739,0.0001245183,0.0002191211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005908266,0.00001765294,0.02070292,0.00008147814,0.0000921648,0.000008508068,0.000500268,0.00001151606,0.9732658,0.000009815967,0.0002051709,0.005045623],"study_design_scores_gemma":[0.0006165713,0.0001833035,0.09799782,0.00001773933,0.00007746449,0.00001314685,0.0003571643,0.00008182842,0.8998404,0.00001159063,0.0004950538,0.0003079161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896569,0.008217581,0.0009125504,0.0007429725,0.00008588842,0.0002218319,0.00004379953,0.00003543187,0.00008301005],"genre_scores_gemma":[0.9976584,0.0006854198,0.0001856833,0.0008352227,0.0003930081,0.00003961288,0.0000882383,0.00003881055,0.00007562341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0772949,"threshold_uncertainty_score":0.9999749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02138624430102764,"score_gpt":0.2228420013650771,"score_spread":0.2014557570640495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}