{"id":"W2999126010","doi":"10.1089/cbr.2019.3141","title":"The Monoclonal Antibody NEO-201 Enhances Natural Killer Cell Cytotoxicity Against Tumor Cells Through Blockade of the Inhibitory CEACAM5/CEACAM1 Immune Checkpoint Pathway","year":2020,"lang":"en","type":"article","venue":"Cancer Biotherapy and Radiopharmaceuticals","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision BioLogic (Canada)","funders":"","keywords":"Cytotoxicity; Lymphokine-activated killer cell; Cancer research; NK-92; Biology; Antibody; Interleukin 21; Interleukin 12; Monoclonal antibody; Immune system; Cancer cell; Innate immune system; Natural killer cell; Carcinoembryonic antigen; Cell culture; Cytotoxic T cell; In vitro; Immunology; Cancer; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008860556,0.0003202574,0.0002302605,0.0001553323,0.00007325044,0.0001729318,0.0001799055,0.0001983697,0.001720383],"category_scores_gemma":[0.00007814023,0.00007965668,0.0001954299,0.00008195394,0.0001362864,0.0001422315,0.0001427591,0.0005150121,0.0003285908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002532102,"about_ca_system_score_gemma":0.0002253813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003309973,"about_ca_topic_score_gemma":0.0005641034,"domain_scores_codex":[0.9999021,0.00001352686,0.000009632598,0.00001328534,0.00002836754,0.00003307146],"domain_scores_gemma":[0.999949,0.00001240581,0.00001089364,0.000005431536,0.00000838367,0.00001398497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001225475,0.0001015358,0.0001526116,0.00004145402,0.000004965229,0.00002533285,0.000005058482,0.00004757811,0.9978306,0.00004915722,0.00004117869,0.001578008],"study_design_scores_gemma":[0.00003683314,0.00101107,0.002011548,0.000004841225,0.00001959984,0.0001982187,0.000007342598,0.0004668764,0.9949712,0.00001524367,0.001255142,0.000002072438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954227,0.001251982,0.001029638,0.00007070966,0.00003107487,0.00003381974,0.00008122991,0.00006203957,0.002016957],"genre_scores_gemma":[0.9966047,0.0005340453,0.0009934043,0.00004704529,0.00001024074,0.0000256386,0.0002271819,0.000006205441,0.00155153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001720383,"threshold_uncertainty_score":0.005755186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02760538254813149,"score_gpt":0.3385589504733103,"score_spread":0.3109535679251788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}