{"id":"W2999126010","doi":"10.1089/cbr.2019.3141","title":"The Monoclonal Antibody NEO-201 Enhances Natural Killer Cell Cytotoxicity Against Tumor Cells Through Blockade of the Inhibitory CEACAM5/CEACAM1 Immune Checkpoint Pathway","year":2020,"lang":"en","type":"article","venue":"Cancer Biotherapy and Radiopharmaceuticals","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision BioLogic (Canada)","funders":"","keywords":"Cytotoxicity; Lymphokine-activated killer cell; Cancer research; NK-92; Biology; Antibody; Interleukin 21; Interleukin 12; Monoclonal antibody; Immune system; Cancer cell; Innate immune system; Natural killer cell; Carcinoembryonic antigen; Cell culture; Cytotoxic T cell; In vitro; Immunology; Cancer; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003654593,0.0004036784,0.0006450324,0.00003518724,0.0005258693,0.00005443011,0.0004486293,0.0001461955,0.0002435369],"category_scores_gemma":[0.00003409896,0.0002087761,0.0004109878,0.0003764127,0.00136593,0.0001188189,0.0001717263,0.0009989237,0.00001306716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000707709,"about_ca_system_score_gemma":0.0003406237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008832684,"about_ca_topic_score_gemma":0.000003502045,"domain_scores_codex":[0.9972123,0.0002388542,0.0006894398,0.0005221668,0.0006711638,0.0006660977],"domain_scores_gemma":[0.9986309,0.000311424,0.0002483617,0.0003367678,0.0001235722,0.000348922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001767595,0.0001445093,0.001407153,0.0003640895,0.0002420509,0.00003056256,0.0009374451,0.00001092686,0.9911456,0.000114668,0.0008903746,0.002945026],"study_design_scores_gemma":[0.0018329,0.0001976283,0.003383657,0.0001472011,0.00005056795,0.00001997538,0.0001432287,0.0009509454,0.8478137,0.00002815328,0.1451925,0.0002395386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8941501,0.08359373,0.00001471191,0.01957647,0.000898611,0.000896197,0.0001021088,0.00003810891,0.0007299291],"genre_scores_gemma":[0.9319786,0.05860226,0.0001557779,0.006741387,0.001031496,0.00004212662,0.00001050336,0.00004454383,0.001393288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1443021,"threshold_uncertainty_score":0.851364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02760538254813149,"score_gpt":0.3385589504733103,"score_spread":0.3109535679251788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}