{"id":"W2999138060","doi":"10.1021/acsinfecdis.9b00365","title":"Cariogenic <i>Streptococcus mutans</i> Produces Tetramic Acid Strain-Specific Antibiotics That Impair Commensal Colonization","year":2020,"lang":"en","type":"letter","venue":"ACS Infectious Diseases","topic":"Oral microbiology and periodontitis research","field":"Dentistry","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; National Institute of Dental and Craniofacial Research; Japan Society for the Promotion of Science","keywords":"Streptococcus mutans; Microbiology; Nonribosomal peptide; Polyketide synthase; Dysbiosis; Biology; Bacteria; Dental plaque; Polyketide; Biofilm; Antibiotics; Biosynthesis; Enzyme; Biochemistry; Gut flora; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008193466,0.0006224337,0.000531405,0.0004311349,0.001923037,0.001830272,0.0006627562,0.02423931,0.005922652],"category_scores_gemma":[0.006130571,0.0004107355,0.0006085618,0.0003712886,0.00125929,0.001089806,0.0005387376,0.01159478,0.005717999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002545934,"about_ca_system_score_gemma":0.001726952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006332101,"about_ca_topic_score_gemma":0.008609551,"domain_scores_codex":[0.9991933,0.0002372879,0.00007738902,0.00009880117,0.0002188658,0.0001744223],"domain_scores_gemma":[0.9985159,0.0007180912,0.0001139669,0.00006568879,0.000315194,0.0002711626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009821205,0.00008868117,0.002842212,0.0000578096,0.00001555447,0.01946506,0.0001714377,0.00009341584,0.0009598744,0.003745648,0.9526596,0.01980245],"study_design_scores_gemma":[0.0001281461,0.0002084215,0.003615996,0.0001888664,0.00003277727,0.029539,0.0007305942,0.0008217295,0.000874971,0.009435535,0.9543651,0.00005877541],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.003774319,0.001491849,0.0001713587,0.9635978,0.01489266,0.00002001746,0.00007139309,0.00006628541,0.01591437],"genre_scores_gemma":[0.0426203,0.003024808,0.0006333658,0.8744314,0.05066391,0.00004694154,0.00009645816,0.00004074884,0.02844193],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02423931,"threshold_uncertainty_score":0.01981324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02391210066311882,"score_gpt":0.2702298309290458,"score_spread":0.246317730265927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}