{"id":"W2999244147","doi":"10.1016/j.chembiol.2019.12.008","title":"Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2","year":2020,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Structural Genomics Consortium; Ontario Genomics; University of Toronto","funders":"Argonne National Laboratory; Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Janssen Pharmaceuticals; Biological and Environmental Research; National Institute of Allergy and Infectious Diseases; Takeda Canada; Canadian Institutes of Health Research; Innovative Medicines Initiative; Novartis Pharma; Canada Foundation for Innovation; Meso Scale Diagnostics; Ministerio de Educación, Cultura y Deporte; Merck; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Canadian Institute for Advanced Research; U.S. Department of Energy; Pfizer; National Institutes of Health; Canada Research Chairs; U.S. Department of Health and Human Services; Boehringer Ingelheim","keywords":"Caspofungin; Echinocandins; Echinocandin; Candida albicans; Corpus albicans; Kinase; Drug resistance; Fungal pathogen; Microbiology; Biology; Antifungal drug; Antifungal; Pharmacology; Pathogen; Biochemistry; Amphotericin B; Fluconazole","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007121956,0.0001338542,0.0003201252,0.000009714151,0.00005173214,0.000004128649,0.0001229401,0.0001907941,0.0001574886],"category_scores_gemma":[0.0001937826,0.00009253626,0.0001639397,0.0001667108,0.0003556293,0.00003603923,0.0001053995,0.0003104005,0.00001532312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004366156,"about_ca_system_score_gemma":0.0000750324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001800809,"about_ca_topic_score_gemma":0.00001220374,"domain_scores_codex":[0.9989659,0.00004966527,0.0002963002,0.0003382098,0.000123965,0.000225911],"domain_scores_gemma":[0.9993713,0.00008997622,0.0001154679,0.0002720965,0.00006191688,0.00008922382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006015148,0.00009650808,0.04813609,0.0002825956,0.00001217885,0.000009774883,0.0002229546,3.321136e-7,0.9486443,0.0003248776,0.001627253,0.00004161098],"study_design_scores_gemma":[0.000866843,0.00007206447,0.004517085,0.00008720772,0.00004493463,0.000001218046,0.0001125157,0.00002666154,0.9929577,0.0004638419,0.0007564232,0.00009349379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991155,0.0003094997,0.0003559153,0.001376186,0.00009092366,0.0002086705,0.00005902016,0.00002151377,0.006423286],"genre_scores_gemma":[0.998395,0.00002432381,0.0003006675,0.0007931846,0.0002227305,0.000003986722,0.00004125985,0.00001037506,0.0002084959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0443134,"threshold_uncertainty_score":0.3773519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01598509366014137,"score_gpt":0.2632149904132043,"score_spread":0.2472298967530629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}