{"id":"W2999244147","doi":"10.1016/j.chembiol.2019.12.008","title":"Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2","year":2020,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Structural Genomics Consortium; Ontario Genomics; University of Toronto","funders":"Argonne National Laboratory; Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Janssen Pharmaceuticals; Biological and Environmental Research; National Institute of Allergy and Infectious Diseases; Takeda Canada; Canadian Institutes of Health Research; Innovative Medicines Initiative; Novartis Pharma; Canada Foundation for Innovation; Meso Scale Diagnostics; Ministerio de Educación, Cultura y Deporte; Merck; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Canadian Institute for Advanced Research; U.S. Department of Energy; Pfizer; National Institutes of Health; Canada Research Chairs; U.S. Department of Health and Human Services; Boehringer Ingelheim","keywords":"Caspofungin; Echinocandins; Echinocandin; Candida albicans; Corpus albicans; Kinase; Drug resistance; Fungal pathogen; Microbiology; Biology; Antifungal drug; Antifungal; Pharmacology; Pathogen; Biochemistry; Amphotericin B; Fluconazole","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009506218,0.0003057509,0.0002307825,0.0001660461,0.0001685015,0.0003602054,0.0002485631,0.0001582902,0.001454098],"category_scores_gemma":[0.00007906654,0.0000817683,0.0001491877,0.0001581344,0.0001579121,0.0002656661,0.0002605961,0.0004973215,0.0002777348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003798273,"about_ca_system_score_gemma":0.0002862317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005052492,"about_ca_topic_score_gemma":0.001179321,"domain_scores_codex":[0.9999239,0.000007345894,0.000006529064,0.00001508243,0.00002180844,0.00002519236],"domain_scores_gemma":[0.9999655,0.000004625579,0.000009788391,0.000003762284,0.000005366809,0.000010977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002075506,0.00003243812,0.0001408681,0.00005621871,0.000007116309,0.00005161325,0.00001002811,0.0001688548,0.9954904,0.0002895897,0.0001674986,0.003377885],"study_design_scores_gemma":[0.00003561456,0.0001415217,0.0015851,0.000004110593,0.00001122369,0.0001773329,0.00002641506,0.001395944,0.9904047,0.00007556996,0.006136831,0.000005549774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846245,0.004426962,0.004393512,0.0004834037,0.0001005909,0.00004088788,0.000514671,0.0002322287,0.005183193],"genre_scores_gemma":[0.9932998,0.001466637,0.00156655,0.00005400157,0.000009466239,0.00001978986,0.0003296801,0.00001839464,0.003235569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001454098,"threshold_uncertainty_score":0.004864395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01598509366014137,"score_gpt":0.2632149904132043,"score_spread":0.2472298967530629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}