{"id":"W2999274201","doi":"10.1002/da.22991","title":"The genetic and environmental hierarchical structure of anxiety and depression in the UK Biobank","year":2020,"lang":"en","type":"article","venue":"Depression and Anxiety","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Research Unit on Children's Psychosocial Maladjustment","funders":"Medical Research Council; Fonds de Recherche du Québec-Société et Culture; King's College London; National Institute for Health and Care Research; Maudsley Charity; Department of Health and Social Care; Economic and Social Research Council; South London and Maudsley NHS Foundation Trust; Alexander von Humboldt-Stiftung","keywords":"Loneliness; Anxiety; Biobank; Distress; Psychosocial; Psychology; Clinical psychology; Depression (economics); Psychiatry; Mental health; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001452372,0.0001864784,0.000386767,0.001718964,0.0005472898,0.0006934649,0.000436778,0.0003943637,0.003888176],"category_scores_gemma":[0.008410536,0.0002806179,0.000357084,0.004535507,0.0003620557,0.0003026157,0.001201193,0.0003718006,0.0004518595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008768769,"about_ca_system_score_gemma":0.0006465353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.05596416,"about_ca_topic_score_gemma":0.06103561,"domain_scores_codex":[0.9978272,0.0009301529,0.0002963838,0.000509176,0.0002391905,0.0001977426],"domain_scores_gemma":[0.9955721,0.00131776,0.00178866,0.0006840087,0.0004299878,0.0002075364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001248996,0.00001943768,0.9913055,0.00007313869,0.0001691613,0.0002233234,0.0007435202,0.0001651883,0.0008193605,0.0003960565,0.001326662,0.004633756],"study_design_scores_gemma":[0.000009193562,0.00001430006,0.9985588,0.00002900268,0.0000359427,0.0001499071,0.0001491215,0.0001600291,0.00006739551,0.0001936615,0.0006276225,0.000005113071],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863293,0.0006037183,0.00106559,0.0003219428,0.000009896621,0.00005079531,0.01032012,0.000009436292,0.001289254],"genre_scores_gemma":[0.9923635,0.0003301294,0.001197777,0.00008909172,0.000007984467,0.0001019816,0.005445839,0.000006638472,0.0004570518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05596416,"threshold_uncertainty_score":0.1112769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005917524833056915,"score_gpt":0.2233591080369389,"score_spread":0.217441583203882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}