{"id":"W2999274201","doi":"10.1002/da.22991","title":"The genetic and environmental hierarchical structure of anxiety and depression in the UK Biobank","year":2020,"lang":"en","type":"article","venue":"Depression and Anxiety","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Research Unit on Children's Psychosocial Maladjustment","funders":"Medical Research Council; Fonds de Recherche du Québec-Société et Culture; King's College London; National Institute for Health and Care Research; Maudsley Charity; Department of Health and Social Care; Economic and Social Research Council; South London and Maudsley NHS Foundation Trust; Alexander von Humboldt-Stiftung","keywords":"Loneliness; Anxiety; Biobank; Distress; Psychosocial; Psychology; Clinical psychology; Depression (economics); Psychiatry; Mental health; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001218974,0.00009741126,0.0001084706,0.000007570968,0.0001457684,0.00001417358,0.00009655932,0.0001338743,0.000005319407],"category_scores_gemma":[0.00007366062,0.00005333299,0.0000263074,0.00003264527,0.0001648416,0.00000183805,0.0001731052,0.0001226119,1.278446e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001710632,"about_ca_system_score_gemma":0.000007631404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001052727,"about_ca_topic_score_gemma":0.00001600457,"domain_scores_codex":[0.999234,0.0001464229,0.000159806,0.0002537472,0.00007324895,0.0001327643],"domain_scores_gemma":[0.9996886,0.00004000418,0.00006276443,0.0001397112,0.000005854771,0.00006305646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003281292,0.000007886576,0.7996761,0.000006053834,0.000007257667,2.919636e-7,0.0002285762,0.00001162205,0.1736737,0.000006998053,0.0005316252,0.02581702],"study_design_scores_gemma":[0.0004005329,0.00005013064,0.9835964,0.000005966307,0.00001085904,0.00002526548,0.0004336897,0.0008225283,0.00536928,0.0001357985,0.009070239,0.00007935302],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932686,0.005788479,0.0001209085,0.0006047509,0.00002312909,0.0001174921,0.00003153912,0.000001825018,0.00004326599],"genre_scores_gemma":[0.9878168,0.01103216,0.0003784733,0.0006589289,0.0000661333,0.000004443418,0.00002941981,0.000005459759,0.00000819482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1839202,"threshold_uncertainty_score":0.2174856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005917524833056915,"score_gpt":0.2233591080369389,"score_spread":0.217441583203882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}