{"id":"W2999276655","doi":"10.1038/s41467-019-13855-2","title":"Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Public Health Ontario; BC Cancer Agency; Princess Margaret Cancer Centre; University of Toronto; University Health Network; Institut universitaire de cardiologie et de pneumologie de Québec; Université Laval; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"National Cancer Institute; Medical Research Council; Canadian Institutes of Health Research; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; Government of Canada; University of Bristol; Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Institute for Health and Care Research; World Health Organization; Roy Castle Lung Cancer Foundation; Université Laval; Centre International de Recherche sur le Cancer; U.S. Department of Health and Human Services; National Institutes of Health; Cancer Research UK; University Hospitals Bristol NHS Foundation Trust","keywords":"Lung cancer; Immune system; Medicine; Pulmonary function testing; Biology; Lung; Immunology; Cancer research; Genetics; Bioinformatics; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00033681,0.0001755371,0.0001607245,0.00007583247,0.0001782206,0.00002694599,0.0007943669,0.0004529102,0.00004161775],"category_scores_gemma":[0.0005541944,0.0001903004,0.0001029029,0.0004970064,0.00008863277,0.000007604335,0.0007927478,0.00108556,0.000008947583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001501111,"about_ca_system_score_gemma":0.0003159999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000349093,"about_ca_topic_score_gemma":0.001092578,"domain_scores_codex":[0.9982781,0.0003752955,0.0003599717,0.0004503807,0.0002270448,0.0003091534],"domain_scores_gemma":[0.9980438,0.000052597,0.0001100411,0.001434042,0.0001974852,0.0001620483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003069636,0.0001817274,0.003333658,0.00003690211,0.00006061577,0.000006369516,0.0001117842,0.0006338233,0.9918946,0.00006490561,0.001078387,0.002290243],"study_design_scores_gemma":[0.008207404,0.001677701,0.323449,0.0004314066,0.0003400196,0.00005438813,0.001470359,0.2610896,0.2913792,0.00023321,0.1091133,0.002554425],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8916023,0.09427388,0.002761323,0.00726773,0.000258577,0.001828271,0.0003075379,0.0001164468,0.001583932],"genre_scores_gemma":[0.9929757,0.003819253,0.0009965403,0.000866928,0.0001127785,0.0002303768,0.000940391,0.00003541975,0.00002263302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7005154,"threshold_uncertainty_score":0.7760226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01573068650478057,"score_gpt":0.2972254553319942,"score_spread":0.2814947688272137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}