{"id":"W2999304491","doi":"10.1016/j.molcel.2019.12.027","title":"Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks","year":2020,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; Princess Margaret Cancer Centre; Hospital for Sick Children; University of Toronto; Ontario Institute for Cancer Research","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Institute for Cancer Research; Eesti Teadusagentuur; University of Toronto; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Biology; Chromatin; Genetics; Gene; Computational biology; Genome; Carcinogenesis; Epigenetics; Indel; Exome; Exome sequencing; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001845866,0.000405237,0.0003096566,0.001075183,0.0003117046,0.0003789837,0.0004494219,0.0006648229,0.00521574],"category_scores_gemma":[0.0005750092,0.0002009616,0.0003040023,0.0005974663,0.0003644912,0.0001607396,0.0004130758,0.0003795133,0.0005164957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002824161,"about_ca_system_score_gemma":0.0002543278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0013009,"about_ca_topic_score_gemma":0.002761092,"domain_scores_codex":[0.9997893,0.00002301935,0.00002308825,0.00005663086,0.0000774764,0.00003048975],"domain_scores_gemma":[0.9995846,0.0001324169,0.000124492,0.00002701642,0.00002697569,0.0001045062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00156148,0.0001326473,0.06392574,0.0001415678,0.0002927028,0.008485096,0.0001413824,0.003289349,0.9046143,0.003007448,0.0004970249,0.01391121],"study_design_scores_gemma":[0.000239679,0.0004895101,0.5740147,0.00004700679,0.0008208227,0.04153785,0.0003303568,0.01862564,0.3515223,0.003227364,0.009065378,0.00007930282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946526,0.0004465407,0.002395877,0.00007897186,0.00001646074,0.00001927482,0.000552805,0.0001097084,0.001727686],"genre_scores_gemma":[0.9982798,0.00007047559,0.0006751803,0.00002741295,0.000005272495,0.000005805566,0.0002021452,0.00002399161,0.0007099835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00521574,"threshold_uncertainty_score":0.01744837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00433472809090435,"score_gpt":0.2174485476374324,"score_spread":0.2131138195465281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}