{"id":"W2999306985","doi":"10.1016/j.jmb.2020.01.002","title":"Oncogenic K-Ras4B Dimerization Enhances Downstream Mitogen-activated Protein Kinase Signaling","year":2020,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institutes of Health; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; National Cancer Institute; Western University","keywords":"Effector; MAPK/ERK pathway; Kinase; Cell biology; Protein kinase domain; Protein kinase B; Phosphorylation; Mutant; Allosteric regulation; Biology; Chemistry; Molecular biology; Biochemistry; Gene; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002303095,0.0002112661,0.0002972313,0.00008409095,0.00006931172,0.00002385135,0.0002468658,0.0002362436,0.00006305272],"category_scores_gemma":[0.0002842424,0.0001872946,0.0002413948,0.0002134586,0.00009285183,0.000009816394,0.00007285329,0.0001908223,0.00001047827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001828134,"about_ca_system_score_gemma":0.0001834396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002963386,"about_ca_topic_score_gemma":4.306968e-7,"domain_scores_codex":[0.9985008,0.0002543395,0.0005410361,0.0002906644,0.0001661723,0.0002470103],"domain_scores_gemma":[0.9988064,0.000009875539,0.000543754,0.0001652812,0.0002706517,0.0002041034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003482568,0.00004282319,0.00009310353,0.00001996899,0.0001428521,0.00003634439,0.00004051994,0.0004022891,0.9948831,0.0001061924,0.00007033945,0.003814216],"study_design_scores_gemma":[0.0008968959,0.0009474566,0.00001837061,0.00003867971,0.00003990873,0.0000600761,0.00003848182,0.00006244329,0.9899967,0.0001690935,0.007523719,0.0002082068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9001244,0.002543406,0.09629738,0.0005779124,0.0001449836,0.0002218321,0.00000916869,0.00001205199,0.00006881916],"genre_scores_gemma":[0.994642,0.00006267737,0.004135318,0.0005713817,0.0004439355,0.00000904315,0.0000795999,0.0000277579,0.00002825834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09451758,"threshold_uncertainty_score":0.7637652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01146467056605895,"score_gpt":0.2600453282300654,"score_spread":0.2485806576640064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}