{"id":"W2999306985","doi":"10.1016/j.jmb.2020.01.002","title":"Oncogenic K-Ras4B Dimerization Enhances Downstream Mitogen-activated Protein Kinase Signaling","year":2020,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institutes of Health; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; National Cancer Institute; Western University","keywords":"Effector; MAPK/ERK pathway; Kinase; Cell biology; Protein kinase domain; Protein kinase B; Phosphorylation; Mutant; Allosteric regulation; Biology; Chemistry; Molecular biology; Biochemistry; Gene; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002882657,0.000410496,0.000272267,0.000396832,0.0004900208,0.0005846878,0.0002505704,0.0004458574,0.004249239],"category_scores_gemma":[0.0002250787,0.0002938616,0.0003751633,0.0002428449,0.0003214089,0.0002529462,0.0004421312,0.001265668,0.001524853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006256099,"about_ca_system_score_gemma":0.0003943581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008919835,"about_ca_topic_score_gemma":0.001718277,"domain_scores_codex":[0.9994733,0.0001092704,0.00003151112,0.00006542139,0.00012708,0.0001934606],"domain_scores_gemma":[0.9997492,0.00003552951,0.0000295799,0.0000355451,0.00002200581,0.000128093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002745886,0.00006681883,0.0001079951,0.00002092811,0.000005273758,0.00003189425,0.000006485175,0.00006575136,0.9985418,0.0002106895,0.0001294556,0.0005383865],"study_design_scores_gemma":[0.00003445783,0.0001704962,0.003387026,0.000004268262,0.00001034744,0.0002047905,0.00004362034,0.001320963,0.9914799,0.00009046934,0.003248072,0.000005385862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910638,0.001229951,0.001372567,0.0004679054,0.0001342213,0.0000337917,0.0005453255,0.0001863602,0.004966034],"genre_scores_gemma":[0.9956564,0.0002773072,0.0006027691,0.00007867999,0.00001626943,0.00001382824,0.0004610511,0.00002148175,0.002872197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004249239,"threshold_uncertainty_score":0.01421511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01146467056605895,"score_gpt":0.2600453282300654,"score_spread":0.2485806576640064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}