{"id":"W2999307972","doi":"10.7554/elife.52649.sa2","title":"Author response: HIV restriction factor APOBEC3G binds in multiple steps and conformations to search and deaminate single-stranded DNA","year":2019,"lang":"en","type":"peer-review","venue":"","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"APOBEC3G; Cytidine deaminase; Infectivity; DNA; Biology; Binding site; Reverse transcriptase; Cell biology; Plasma protein binding; Biophysics; Chemistry; Biochemistry; Genetics; Virus; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00264446,0.0006573428,0.0007187448,0.001487514,0.001298601,0.003946627,0.0009855316,0.003596142,0.3371359],"category_scores_gemma":[0.02764523,0.0003060601,0.0004238433,0.0006783592,0.0008479773,0.001676784,0.001488523,0.002397287,0.1755122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001304862,"about_ca_system_score_gemma":0.00345176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002244362,"about_ca_topic_score_gemma":0.00679693,"domain_scores_codex":[0.9969258,0.0004794145,0.0002264318,0.0003314909,0.001730521,0.0003064694],"domain_scores_gemma":[0.9722139,0.003170925,0.0008090428,0.0007236467,0.01994795,0.003134477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006042998,0.00001559768,0.0002859468,0.0003153615,0.000008498137,0.0001754679,0.00005533127,0.00004400377,0.0005018503,0.0005113938,0.9694361,0.02859005],"study_design_scores_gemma":[0.0000171709,0.00002461352,0.0007671759,0.0001309566,0.000006788895,0.0002187051,0.0001573805,0.0000574196,0.0003849597,0.0004631709,0.9977599,0.00001173533],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"commentary","genre_scores_codex":[0.004459317,0.009563496,0.002093764,0.2955956,0.5017352,0.0005978581,0.002770836,0.00128939,0.1818946],"genre_scores_gemma":[0.01261385,0.005537476,0.001152241,0.02739931,0.04860692,0.00008946077,0.001174886,0.0004866308,0.9029391],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.3371359,"threshold_uncertainty_score":0.9454952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07648752302251245,"score_gpt":0.3383868111724656,"score_spread":0.2618992881499532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}