{"id":"W2999410272","doi":"10.1007/s00005-019-00566-1","title":"HER2-Positive Breast Cancer Immunotherapy: A Focus on Vaccine Development","year":2020,"lang":"en","type":"review","venue":"Archivum Immunologiae et Therapiae Experimentalis","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emmanuel Bible College; University of Waterloo","funders":"","keywords":"Trastuzumab; Pertuzumab; Immunotherapy; Medicine; Breast cancer; Monoclonal antibody; Immune system; Immunology; Immunogenicity; Antigen; Cancer vaccine; Cancer; Cancer immunotherapy; Clinical trial; Tumor microenvironment; Antibody; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","insufficient_payload"],"category_scores_codex":[0.0005662331,0.002364049,0.004144353,0.0007432898,0.0007444022,0.0001772461,0.002197147,0.00122146,0.003429838],"category_scores_gemma":[0.00003549719,0.001835235,0.001639695,0.000685677,0.0005607269,0.0002830436,0.0006272639,0.002619501,0.002233703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009043101,"about_ca_system_score_gemma":0.001273703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005456321,"about_ca_topic_score_gemma":0.00001429578,"domain_scores_codex":[0.9909309,0.003452249,0.001986143,0.001792913,0.0002453647,0.001592462],"domain_scores_gemma":[0.9959916,0.001054012,0.001209347,0.00156467,0.00009045686,0.0000898705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003690117,0.001115176,0.000003141634,0.0003573596,0.0103455,0.0000621582,0.00492048,3.481485e-7,0.02652632,0.0005150453,0.001556308,0.9509081],"study_design_scores_gemma":[0.003288028,0.001339823,0.0001385604,0.007037617,0.0002706564,0.0006509629,0.0004453546,1.085527e-7,0.03567509,0.00005523005,0.9491709,0.001927591],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002814421,0.9914198,0.00005029603,0.001029712,0.001863557,0.002557452,0.001025093,0.0009304089,0.0008422227],"genre_scores_gemma":[0.0009930742,0.990844,0.0001898058,0.001434214,0.0001304598,0.002387629,0.001438857,0.0006699135,0.001912038],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9489805,"threshold_uncertainty_score":0.9996815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.024162047100398,"score_gpt":0.3206140666405289,"score_spread":0.296452019540131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}