{"id":"W2999438210","doi":"10.1101/2020.01.20.912931","title":"Crystal structure and interaction studies of human DHTKD1 provide insight into a mitochondrial megacomplex in lysine catabolism","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero dello Sviluppo Economico; Fundação de Amparo à Pesquisa do Estado de São Paulo; European Federation of Pharmaceutical Industries and Associations; Novartis Pharma; Wellcome Trust; Ontario Ministry of Economic Development and Innovation; Genome Canada; Pfizer","keywords":"Cofactor; Biochemistry; Catabolism; Lysine; Oxidoreductase; Dehydrogenase; Biology; Chemistry; Missense mutation; Mitochondrion; Oxidative decarboxylation; Enzyme; Amino acid; Mutation; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001977659,0.000520174,0.0004610496,0.0002012811,0.0004738681,0.0005362434,0.0005971264,0.0004906209,0.00212765],"category_scores_gemma":[0.0002731109,0.0002956824,0.0003421313,0.0002991908,0.0001804396,0.0003156968,0.000363044,0.0009959651,0.0003695019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001207538,"about_ca_system_score_gemma":0.0003843377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004047014,"about_ca_topic_score_gemma":0.004699164,"domain_scores_codex":[0.9999064,0.00001387641,0.00000671198,0.0000244465,0.00002996256,0.00001867835],"domain_scores_gemma":[0.9999061,0.00002438955,0.00001599476,0.00000523556,0.00001532778,0.00003290475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001116364,0.0005106973,0.01660002,0.000954342,0.0003124877,0.002293526,0.0005199551,0.01328176,0.9408041,0.002104053,0.006931855,0.01457091],"study_design_scores_gemma":[0.0009422026,0.0008700592,0.1056866,0.0001563362,0.0006072469,0.005045821,0.001349466,0.2572916,0.5623178,0.00235634,0.06320635,0.0001701168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874437,0.00544189,0.002769107,0.0006419755,0.00006640753,0.00002989479,0.001535113,0.0001574161,0.001914439],"genre_scores_gemma":[0.9846732,0.001923811,0.006508471,0.0001495578,0.00001218823,0.00001877802,0.005420945,0.00003102104,0.001261994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004047014,"threshold_uncertainty_score":0.008761406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0226222156360545,"score_gpt":0.2866997774089838,"score_spread":0.2640775617729293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}