{"id":"W2999444015","doi":"10.1002/hep.31115","title":"Indole Alleviates Diet‐Induced Hepatic Steatosis and Inflammation in a Manner Involving Myeloid Cell 6‐Phosphofructo‐2‐Kinase/Fructose‐2,6‐Biphosphatase 3","year":2020,"lang":"en","type":"article","venue":"Hepatology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canada Economic Development for Quebec Regions; U.S. Department of Veterans Affairs; National Institute on Alcohol Abuse and Alcoholism; National Institute of Food and Agriculture; National Institutes of Health; American Diabetes Association","keywords":"Steatosis; Inflammation; Indole test; Fatty liver; Proinflammatory cytokine; Internal medicine; Biology; Endocrinology; Fructose; Nonalcoholic fatty liver disease; Myeloid; Cancer research; Immunology; Medicine; Biochemistry; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001602097,0.0002664608,0.0003828924,0.00007773076,0.0000994377,0.00002780321,0.0001808557,0.0003249362,0.00004466658],"category_scores_gemma":[0.0001091681,0.0002747917,0.00006149239,0.0001757227,0.00007723876,0.00001723219,0.0002284119,0.0002210391,0.00003713486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003180143,"about_ca_system_score_gemma":0.0001350956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003775967,"about_ca_topic_score_gemma":0.0006501026,"domain_scores_codex":[0.9982547,0.0001582187,0.0004516509,0.0005884354,0.00008746848,0.0004594836],"domain_scores_gemma":[0.9992974,0.00002644728,0.0001571736,0.0002570598,0.00005687045,0.0002050705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002677492,0.00004528342,0.1516663,0.0002379934,0.00002142568,0.00002888832,0.0005882897,0.000005027658,0.8452771,0.0001714516,0.0006841658,0.001006386],"study_design_scores_gemma":[0.003009601,0.001158208,0.03350022,0.00005648631,0.00004482835,0.00003086829,0.0005133635,0.001802464,0.9438996,0.0001649335,0.01515435,0.000665066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934249,0.00426853,0.0000343053,0.001619438,0.0001184982,0.0003795638,0.00002829282,0.00002711833,0.00009938527],"genre_scores_gemma":[0.99533,0.001636392,0.0004294582,0.002111266,0.0001169775,0.00004103295,0.0002642969,0.00003711824,0.00003342501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1181661,"threshold_uncertainty_score":0.9999704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01342006655194449,"score_gpt":0.2287555386792725,"score_spread":0.215335472127328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}