{"id":"W2999450347","doi":"10.1016/j.immuni.2019.12.007","title":"Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells","year":2020,"lang":"en","type":"article","venue":"Immunity","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":227,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Blood Cancer UK; National Institute for Health and Care Research; Cancer Research UK; Crohn's and Colitis Foundation; Wellcome Trust; Bloodwise; Francis Crick Institute; Department of Health and Aged Care, Australian Government; Canadian Institute for Theoretical Astrophysics; Medical Research Council; Cancer Research Institute","keywords":"Cytotoxic T cell; Biology; Function (biology); Cell biology; Interleukin 2; Immunology; Immune system; Genetics; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002700318,0.0001922551,0.0002677546,0.000090864,0.0001745977,0.0000212001,0.0001546454,0.0002614303,0.001903237],"category_scores_gemma":[0.00003040669,0.0001940065,0.00009328759,0.0001254287,0.0001885819,0.0002305809,0.0001066245,0.0005129395,0.0003859976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005276392,"about_ca_system_score_gemma":0.00003016407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001836424,"about_ca_topic_score_gemma":0.000005338513,"domain_scores_codex":[0.9986619,0.0003871945,0.0004179871,0.0002600373,0.00005586926,0.0002169962],"domain_scores_gemma":[0.9992442,0.0000900803,0.0002371513,0.0002982214,0.00009186602,0.00003849716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007245643,0.000122351,0.0001004745,0.00003899142,0.00009671013,8.032101e-7,0.0005872649,0.000006256923,0.9744083,0.00005972798,0.02225795,0.001596586],"study_design_scores_gemma":[0.001131166,0.0007451033,0.003473616,0.00003244225,0.00005466003,0.00001540593,0.001047963,0.00001808441,0.9693103,0.00002793062,0.02396831,0.0001749842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941161,0.001271658,0.0007618315,0.0002710299,0.002072734,0.0002316576,0.00003414975,0.00009576965,0.001145015],"genre_scores_gemma":[0.9958733,0.0001335151,0.00001963759,0.0007067786,0.00003271439,0.000008842611,0.0002081909,0.00001976971,0.002997289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005097992,"threshold_uncertainty_score":0.9990091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01121680600349375,"score_gpt":0.2117439507795986,"score_spread":0.2005271447761049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}