{"id":"W2999450347","doi":"10.1016/j.immuni.2019.12.007","title":"Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells","year":2020,"lang":"en","type":"article","venue":"Immunity","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":227,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Blood Cancer UK; National Institute for Health and Care Research; Cancer Research UK; Crohn's and Colitis Foundation; Wellcome Trust; Bloodwise; Francis Crick Institute; Department of Health and Aged Care, Australian Government; Canadian Institute for Theoretical Astrophysics; Medical Research Council; Cancer Research Institute","keywords":"Cytotoxic T cell; Biology; Function (biology); Cell biology; Interleukin 2; Immunology; Immune system; Genetics; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003676996,0.0006528065,0.0003481717,0.0003732769,0.0001624189,0.0004649214,0.0004290473,0.0004453292,0.00277662],"category_scores_gemma":[0.0003420276,0.0001398199,0.0002623561,0.0001661278,0.000404124,0.0002706184,0.0001821449,0.001416715,0.0006827621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001435177,"about_ca_system_score_gemma":0.0002605263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001135282,"about_ca_topic_score_gemma":0.0001913371,"domain_scores_codex":[0.9996798,0.00008893658,0.00001852764,0.00004496877,0.00006201761,0.0001058834],"domain_scores_gemma":[0.9997106,0.00008253218,0.00006974166,0.00004212799,0.00003460733,0.00006040666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004373892,0.0001544084,0.0003543598,0.00006941412,0.000006431452,0.0001448953,0.00002862863,0.0001380731,0.9878712,0.0002758194,0.0001225796,0.01039679],"study_design_scores_gemma":[0.0001619997,0.002081756,0.002428668,0.00002080363,0.00004820171,0.0006679333,0.00006018151,0.0009095296,0.9864391,0.0003714777,0.006802898,0.000007405061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808514,0.004289114,0.006941143,0.0002365524,0.0002583563,0.0001248905,0.000150284,0.0003332057,0.006814891],"genre_scores_gemma":[0.9902585,0.001236462,0.00390927,0.0001367117,0.0001770992,0.00006222342,0.0001826192,0.00004496847,0.003992272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00277662,"threshold_uncertainty_score":0.009288728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01121680600349375,"score_gpt":0.2117439507795986,"score_spread":0.2005271447761049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}