{"id":"W2999460683","doi":"10.1101/2020.01.16.908186","title":"A comparative ‘omics approach to candidate pathogenicity factor discovery in the brain-eating amoeba <i>Naegleria fowleri</i>","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Alberta","funders":"Alberta Heritage Foundation for Medical Research; Grantová Agentura České Republiky; Commonwealth Scientific and Industrial Research Organisation","keywords":"Naegleria fowleri; Biology; Pathogenicity island; Pathogenicity; Genome; Microbiology; Transcriptome; Genetics; Virology; Gene; Meningoencephalitis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007944378,0.000626458,0.0007745728,0.00178161,0.0007613199,0.001615403,0.0003613933,0.0005839373,0.001742985],"category_scores_gemma":[0.0005987537,0.0002714516,0.001009639,0.001240691,0.0003197582,0.0004753003,0.0005935706,0.0007026239,0.0006726957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006960963,"about_ca_system_score_gemma":0.0006614453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001244733,"about_ca_topic_score_gemma":0.001769364,"domain_scores_codex":[0.9996434,0.00005997113,0.00002725668,0.0001334171,0.00009000209,0.00004593824],"domain_scores_gemma":[0.9997018,0.0001132109,0.00005790907,0.00003883081,0.00005284547,0.00003543511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005783326,0.0001037638,0.008800122,0.0007763492,0.0002411131,0.0005628654,0.0001818397,0.001077546,0.9626978,0.001261684,0.002033083,0.02168559],"study_design_scores_gemma":[0.0001811939,0.001033937,0.2663069,0.0004543048,0.001122744,0.002890025,0.001577162,0.05016909,0.5556859,0.01038367,0.11003,0.000165147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8325384,0.01295033,0.08449683,0.002522731,0.0003300807,0.0002572555,0.05536904,0.002258374,0.009277097],"genre_scores_gemma":[0.7517112,0.005381842,0.1606233,0.001224207,0.0001505058,0.0002835403,0.07714071,0.0003447781,0.003139744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00178161,"threshold_uncertainty_score":0.005830884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02935494447558638,"score_gpt":0.2643060183861409,"score_spread":0.2349510739105545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}