{"id":"W2999473311","doi":"10.2337/db19-0713","title":"PI3Kδ as a Novel Therapeutic Target in Pathological Angiogenesis","year":2020,"lang":"en","type":"article","venue":"Diabetes","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Eye Institute; Cancer Research UK","keywords":"Diabetic retinopathy; Angiogenesis; Retinopathy; PI3K/AKT/mTOR pathway; Downregulation and upregulation; Fibroblast growth factor; Medicine; Cancer research; Diabetes mellitus; Growth factor; Proliferative vitreoretinopathy; P110α; Vascular endothelial growth factor; Retinal; Endothelial stem cell; Biology; Endocrinology; Internal medicine; Receptor; Cell biology; Retinal detachment; Ophthalmology; Signal transduction; VEGF receptors; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002122137,0.0003655895,0.0003331673,0.0002985454,0.0001791103,0.0005558046,0.0003021856,0.000396744,0.001302719],"category_scores_gemma":[0.00006892884,0.0000922023,0.0002571881,0.0002642033,0.0002340349,0.0003320726,0.0002698525,0.001397419,0.0003187365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004009924,"about_ca_system_score_gemma":0.0004138588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002787154,"about_ca_topic_score_gemma":0.0007964825,"domain_scores_codex":[0.9999393,0.000009404302,0.000004734452,0.00001200377,0.0000135205,0.0000210421],"domain_scores_gemma":[0.9999779,0.000003352617,0.000005001829,0.000002381201,0.000003982523,0.000007368512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002880471,0.001474094,0.001605668,0.002285111,0.0001431998,0.001605845,0.0001434558,0.001392808,0.5949536,0.01236778,0.006642458,0.3745054],"study_design_scores_gemma":[0.002944201,0.009529213,0.01547982,0.0006568425,0.0006397388,0.007599866,0.0002989098,0.005841975,0.555989,0.01179373,0.38915,0.00007681908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4796025,0.4569755,0.01933779,0.009170721,0.001397893,0.0003888933,0.0007365801,0.000578354,0.03181182],"genre_scores_gemma":[0.8354636,0.1461349,0.008476156,0.001609212,0.0002981647,0.0001793311,0.0005459546,0.00003108216,0.007261454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001302719,"threshold_uncertainty_score":0.004358053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0323299048887575,"score_gpt":0.276808889654836,"score_spread":0.2444789847660785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}