{"id":"W2999473311","doi":"10.2337/db19-0713","title":"PI3Kδ as a Novel Therapeutic Target in Pathological Angiogenesis","year":2020,"lang":"en","type":"article","venue":"Diabetes","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Eye Institute; Cancer Research UK","keywords":"Diabetic retinopathy; Angiogenesis; Retinopathy; PI3K/AKT/mTOR pathway; Downregulation and upregulation; Fibroblast growth factor; Medicine; Cancer research; Diabetes mellitus; Growth factor; Proliferative vitreoretinopathy; P110α; Vascular endothelial growth factor; Retinal; Endothelial stem cell; Biology; Endocrinology; Internal medicine; Receptor; Cell biology; Retinal detachment; Ophthalmology; Signal transduction; VEGF receptors; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002596382,0.00009185498,0.0001832501,0.00002532612,0.00001738017,0.000008070366,0.00004059822,0.00004029763,0.0002407597],"category_scores_gemma":[0.00005924481,0.00006483275,0.0001001962,0.0001414214,0.00002477608,0.00002122417,0.00001974256,0.00004302544,0.0001618261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001376786,"about_ca_system_score_gemma":0.00002051264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005900175,"about_ca_topic_score_gemma":1.165489e-7,"domain_scores_codex":[0.9994222,0.00001617424,0.00009957703,0.0001783859,0.0001052306,0.0001784182],"domain_scores_gemma":[0.9997097,0.00003080314,0.00001866943,0.00008566841,0.00001477711,0.0001404299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007155306,0.0003511819,0.968354,0.0000338491,0.00005579255,0.0001295866,0.00009183157,0.000002276889,0.02782788,0.00013428,0.00006108582,0.002886656],"study_design_scores_gemma":[0.001250577,0.0006015902,0.9898607,0.00002945968,0.00008672042,0.000002122731,0.00005126567,0.0003483948,0.00633906,0.0003911113,0.0009504372,0.00008856682],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941542,0.002126714,0.00001089719,0.00224313,0.00001735482,0.000172346,0.00001340484,0.00003809835,0.001223906],"genre_scores_gemma":[0.9946209,0.0000274972,0.0003541771,0.004835277,0.0000468414,0.00002937589,0.00003329715,0.00001104604,0.00004158064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02150667,"threshold_uncertainty_score":0.2643803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0323299048887575,"score_gpt":0.276808889654836,"score_spread":0.2444789847660785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}