{"id":"W2999546369","doi":"10.3389/fncel.2019.00589","title":"VIP/PACAP-Based Drug Development: The ADNP/NAP-Derived Mirror Peptides SKIP and D-SKIP Exhibit Distinctive in vivo and in silico Effects","year":2020,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Tel Aviv University; McGill University; Israel Science Foundation; Fundación Alicia Koplowitz","keywords":"Neuroprotection; Nap; In silico; Vasoactive intestinal peptide; Biology; Haploinsufficiency; Peptide; In vivo; Neuroscience; Neuropeptide; Phenotype; Gene; Biochemistry; Genetics; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000279182,0.0003527712,0.0004246603,0.0002017055,0.0002535764,0.0001251683,0.0006180184,0.00006438175,0.000003879581],"category_scores_gemma":[0.00115183,0.0002877862,0.0000447692,0.001072729,0.001040903,0.000305242,0.0003699386,0.0005320533,0.000004459309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004995027,"about_ca_system_score_gemma":0.00009775539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000501406,"about_ca_topic_score_gemma":0.00004974603,"domain_scores_codex":[0.996734,0.0005171389,0.0004170068,0.00132918,0.0003308119,0.0006719083],"domain_scores_gemma":[0.9989507,0.0004372638,0.0001420194,0.0002495516,0.00001439705,0.0002060592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001473054,0.00008751781,0.02607138,0.00007555832,4.927566e-7,0.0003405705,0.001000484,0.0001061671,0.9714298,0.00005035483,0.00006920275,0.0006212072],"study_design_scores_gemma":[0.001144815,0.0002148406,0.1265335,0.00009648134,0.000004959246,0.000008478735,0.0002051234,0.02035513,0.8488764,0.0002910816,0.001862815,0.0004064787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976584,0.0002153022,0.0003099962,0.0006248685,0.0003641165,0.000668445,0.000007866059,0.00004163889,0.0001093197],"genre_scores_gemma":[0.9950252,0.00007648134,0.0006011241,0.004142834,0.00002069003,0.00004863362,6.761015e-7,0.0000319769,0.00005239451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1225534,"threshold_uncertainty_score":0.9999574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01853349442016589,"score_gpt":0.2145221986972096,"score_spread":0.1959887042770437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}