{"id":"W2999585294","doi":"10.1101/2020.01.10.901835","title":"Open syntaxin overcomes synaptic transmission defects in diverse <i>C. elegans</i> exocytosis mutants","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Welch Foundation","keywords":"Exocytosis; Syntaxin; Cell biology; Synaptotagmin 1; Mutant; Neurotransmission; Munc-18; Syntaxin 3; STX1A; Protein subunit; Wild type; Chemistry; Biology; Secretion; Synaptic vesicle; Vesicle; Membrane; Biochemistry; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001122641,0.0006609843,0.0003562638,0.0004315476,0.0003125529,0.0003486369,0.000372335,0.0003815235,0.001451423],"category_scores_gemma":[0.0001081084,0.0001947008,0.0002453101,0.0001032909,0.0003905633,0.0002246596,0.0004618092,0.0006387396,0.0003046633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004085867,"about_ca_system_score_gemma":0.000295626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001375862,"about_ca_topic_score_gemma":0.003396204,"domain_scores_codex":[0.9998585,0.00001105358,0.00002800306,0.00003069607,0.00003723101,0.0000345467],"domain_scores_gemma":[0.9997908,0.0000218719,0.00005345515,0.00001628758,0.0000211571,0.00009628924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004397618,0.00002042792,0.00009905413,0.00002938099,0.000004569331,0.0001033516,0.00001045506,0.00005125524,0.9988895,0.00008830371,0.00002684782,0.0006330399],"study_design_scores_gemma":[0.00002719779,0.0002083258,0.007007869,0.00002433548,0.00003843643,0.0005071221,0.00006016578,0.001035972,0.9885136,0.00008733256,0.0024738,0.00001572365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961992,0.0002637011,0.001338342,0.00006375758,0.00002276175,0.00002802875,0.0003287831,0.0001629486,0.001592363],"genre_scores_gemma":[0.9937768,0.000320243,0.002076665,0.00006723947,0.000007937209,0.00003416407,0.0003833,0.0001376211,0.003196073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001451423,"threshold_uncertainty_score":0.004855514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01666351109944442,"score_gpt":0.2248005795667485,"score_spread":0.208137068467304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}