{"id":"W2999644186","doi":"10.1101/2020.01.13.904425","title":"A high-affinity antibody against the CSP N-terminal domain lacks <i>Plasmodium falciparum</i> inhibitory activity","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Malaria Research and Control","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Research Council Canada; Canadian Institutes of Health Research; Canada Research Chairs; National Institutes of Health; Hospital for Sick Children; University of Saskatchewan; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source; Western Economic Diversification Canada; Canadian Institute for Advanced Research; Bill and Melinda Gates Foundation","keywords":"Circumsporozoite protein; Plasmodium falciparum; Immunogen; Epitope; Biology; Monoclonal antibody; Virology; Antibody; Antigen; Malaria vaccine; Glycan; Malaria; Immunology; Molecular biology; Glycoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001796597,0.0003025387,0.0001540066,0.0001055149,0.0001020577,0.0002177492,0.0003374393,0.0003459756,0.001683353],"category_scores_gemma":[0.0001577932,0.0001137266,0.0002508204,0.00007986401,0.0001186822,0.0001563543,0.0001325487,0.0004599515,0.0004856879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002558105,"about_ca_system_score_gemma":0.0001340426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006762662,"about_ca_topic_score_gemma":0.0005413886,"domain_scores_codex":[0.9998684,0.00002234024,0.00001196612,0.00002468361,0.00003989448,0.00003275156],"domain_scores_gemma":[0.9999239,0.00001422074,0.00001199441,0.000009422911,0.00001904584,0.00002126791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005711571,0.00003708539,0.0003155374,0.00004042458,0.00001050437,0.00004376717,0.00000505548,0.0001028505,0.9977835,0.00009110046,0.0001486637,0.001364539],"study_design_scores_gemma":[0.00003034252,0.0005419712,0.003068672,0.000007759736,0.00004105668,0.0005853886,0.00001398439,0.002212284,0.9888034,0.00003353835,0.00465564,0.000005997346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865742,0.001639934,0.007337174,0.0001903831,0.00006995764,0.0000301585,0.0002573223,0.0001075166,0.003793339],"genre_scores_gemma":[0.9936613,0.0003269727,0.003034511,0.0002169786,0.00001209771,0.00001081171,0.0006076072,0.0000122946,0.002117531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001683353,"threshold_uncertainty_score":0.005631387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01794558187492444,"score_gpt":0.2595856693650372,"score_spread":0.2416400874901127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}