{"id":"W2999743029","doi":"10.1002/ijc.32859","title":"Reactive stroma and trastuzumab resistance in HER2‐positive early breast cancer","year":2020,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University; Israel Cancer Research Fund; Breast Cancer Research Foundation","keywords":"Trastuzumab; Breast cancer; Stroma; Oncology; Medicine; Internal medicine; Mammary gland; Cancer; Cancer research; Immunohistochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005213614,0.0001413903,0.0002643888,0.0002209703,0.0001004206,0.0002693197,0.0001154709,0.0001503761,0.0004447086],"category_scores_gemma":[0.0009114015,0.00009066345,0.0002002214,0.0002402032,0.0001182358,0.0001241612,0.0001496833,0.0002359483,0.00005762955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001595905,"about_ca_system_score_gemma":0.0001384517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003938644,"about_ca_topic_score_gemma":0.0008703861,"domain_scores_codex":[0.9998232,0.00007876763,0.00001254354,0.00002273441,0.00003610969,0.00002668582],"domain_scores_gemma":[0.9994255,0.000221743,0.0002150773,0.000028494,0.00003072098,0.00007842051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002508423,0.0001045059,0.9769636,0.00002785219,0.0001131874,0.0002583192,0.00003736145,0.0003429026,0.005779375,0.00002832835,0.00007170132,0.01376436],"study_design_scores_gemma":[0.0001110275,0.0009792413,0.9955576,0.000007005366,0.00009800694,0.0007656341,0.00003131065,0.001052815,0.0009438949,0.00007899148,0.0003699657,0.000004443659],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993444,0.0004566839,0.00003838787,0.00002176191,0.000001491265,0.000002419796,0.00002460549,0.00000115375,0.0001090158],"genre_scores_gemma":[0.9997151,0.00009105147,0.00005031669,0.00001752834,0.000006758229,0.000002269382,0.00005797157,5.073527e-7,0.00005840491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005213614,"threshold_uncertainty_score":0.002757251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02539718033214204,"score_gpt":0.3869598574535021,"score_spread":0.3615626771213601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}