{"id":"W2999765928","doi":"10.1111/jnc.14956","title":"Cellular models for discovering prion disease therapeutics: Progress and challenges","year":2020,"lang":"en","type":"review","venue":"Journal of Neurochemistry","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Disease; Prion protein; Biology; Virology; Infectious disease (medical specialty); Neuroscience; Computational biology; Neurodegeneration; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001500006,0.0008104831,0.001893257,0.001608557,0.0003365692,0.001929231,0.000988217,0.001236174,0.001266529],"category_scores_gemma":[0.00065687,0.0003622534,0.0004506022,0.001196849,0.0007860262,0.002345223,0.000637711,0.002751263,0.001363573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009163587,"about_ca_system_score_gemma":0.001282434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006708705,"about_ca_topic_score_gemma":0.001429368,"domain_scores_codex":[0.9995781,0.00009137988,0.00005846226,0.0000566081,0.0001716236,0.00004384333],"domain_scores_gemma":[0.9993913,0.0002620102,0.00007585657,0.00003871715,0.0001718883,0.00006018527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002661476,0.0002385211,0.0007626627,0.01957038,0.0001568711,0.0007841029,0.000302434,0.0009474359,0.1059146,0.0313214,0.03268465,0.8070508],"study_design_scores_gemma":[0.00002466135,0.0005345827,0.001092458,0.001494294,0.0001779762,0.001439005,0.0001598771,0.0004126424,0.01605232,0.008468282,0.9700832,0.00006064027],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00118419,0.993203,0.002124099,0.001197663,0.0003305455,0.0000193941,0.0000609366,0.00004404806,0.001835929],"genre_scores_gemma":[0.00303969,0.9926707,0.00286707,0.0004064299,0.000250749,0.00002842216,0.0001103013,0.000008705904,0.000617982],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001929231,"threshold_uncertainty_score":0.007932901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08245511239987384,"score_gpt":0.3202211617262586,"score_spread":0.2377660493263847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}