{"id":"W2999779152","doi":"10.1093/cid/ciaa016","title":"Cerebrospinal Fluid Early Fungicidal Activity as a Surrogate Endpoint for Cryptococcal Meningitis Survival in Clinical Trials","year":2020,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fogarty International Center; National Institute of Allergy and Infectious Diseases; Grand Challenges Canada; National Institute of Neurological Disorders and Stroke; Medical Research Council; South African Medical Research Council; Department of Science and Technology, Republic of South Africa; Wellcome Trust; National Department of Health","keywords":"Medicine; Surrogate endpoint; Amphotericin B; Clinical endpoint; Fluconazole; Cryptococcal meningitis; Flucytosine; Internal medicine; Cerebrospinal fluid; Confidence interval; Hazard ratio; Gastroenterology; Meningitis; Pleocytosis; Cryptococcus; Clinical trial; Immunology; Surgery; Antifungal; Microbiology; Biology; Human immunodeficiency virus (HIV)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1254999,0.001110638,0.002548024,0.001159939,0.0003148354,0.002170898,0.0009877444,0.001209534,0.001834922],"category_scores_gemma":[0.09378985,0.0003272587,0.004516462,0.001939,0.0009005029,0.001317196,0.001096335,0.002415573,0.0003535427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000984618,"about_ca_system_score_gemma":0.002349245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002104953,"about_ca_topic_score_gemma":0.0002962594,"domain_scores_codex":[0.8890619,0.09562012,0.006522016,0.002979643,0.004875194,0.0009411243],"domain_scores_gemma":[0.828598,0.1031677,0.04948778,0.008398976,0.007619211,0.002728351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.3879994,0.00132783,0.3226281,0.01492886,0.05446777,0.0003934738,0.000552397,0.0158493,0.00839303,0.002957578,0.006233458,0.1842687],"study_design_scores_gemma":[0.07547056,0.1216854,0.6428832,0.006781274,0.03916689,0.00230846,0.0003984411,0.03921165,0.01872536,0.01209749,0.04092755,0.0003437823],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.801125,0.1230335,0.05258718,0.003066067,0.0009882345,0.006731626,0.0048975,0.0002618586,0.007309],"genre_scores_gemma":[0.9818515,0.003951252,0.007321719,0.0007898705,0.0003285753,0.003836795,0.001440077,0.00003662044,0.0004435886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1254999,"threshold_uncertainty_score":0.6637146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2263715428187479,"score_gpt":0.4844942009636046,"score_spread":0.2581226581448567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}