{"id":"W2999779152","doi":"10.1093/cid/ciaa016","title":"Cerebrospinal Fluid Early Fungicidal Activity as a Surrogate Endpoint for Cryptococcal Meningitis Survival in Clinical Trials","year":2020,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fogarty International Center; National Institute of Allergy and Infectious Diseases; Grand Challenges Canada; National Institute of Neurological Disorders and Stroke; Medical Research Council; South African Medical Research Council; Department of Science and Technology, Republic of South Africa; Wellcome Trust; National Department of Health","keywords":"Medicine; Surrogate endpoint; Amphotericin B; Clinical endpoint; Fluconazole; Cryptococcal meningitis; Flucytosine; Internal medicine; Cerebrospinal fluid; Confidence interval; Hazard ratio; Gastroenterology; Meningitis; Pleocytosis; Cryptococcus; Clinical trial; Immunology; Surgery; Antifungal; Microbiology; Biology; Human immunodeficiency virus (HIV)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003624673,0.0004222812,0.002512477,0.0001224722,0.0002459762,0.00009762268,0.0001331864,0.0003832109,0.0003712405],"category_scores_gemma":[0.03752366,0.0003575254,0.002042878,0.0004380991,0.0004446873,0.0001835571,0.0001768309,0.0008466492,0.0001759959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001010585,"about_ca_system_score_gemma":0.0004267435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001666062,"about_ca_topic_score_gemma":0.0001002622,"domain_scores_codex":[0.9939915,0.001597815,0.002470538,0.0009847048,0.0003451799,0.0006102676],"domain_scores_gemma":[0.9890932,0.00859391,0.0005028086,0.0003909077,0.0003223064,0.001096807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004988373,0.002832394,0.9740822,0.0001795328,0.0006415664,0.0001061427,0.00006696551,0.0000163334,0.0002427299,0.0007485909,0.002994153,0.01310103],"study_design_scores_gemma":[0.01107066,0.0105799,0.9697785,0.0001103704,0.0007598196,0.000008422106,0.0000647866,0.0007563281,0.0001150437,0.0008002645,0.00555962,0.0003962817],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895507,0.0003877057,0.001251061,0.002745109,0.001715969,0.002241243,0.0002957095,0.0003553537,0.001457209],"genre_scores_gemma":[0.9947667,0.0003848051,0.00006385819,0.00128436,0.002890772,0.0004022478,0.00004424368,0.00005808506,0.0001049001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03389898,"threshold_uncertainty_score":0.9998876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2263715428187479,"score_gpt":0.4844942009636046,"score_spread":0.2581226581448567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}