{"id":"W2999860983","doi":"10.1016/j.molcel.2019.10.031","title":"HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells","year":2019,"lang":"en","type":"article","venue":"Molecular Cell","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Structural Genomics Consortium; University of Toronto","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Janssen Pharmaceuticals; U.S. National Library of Medicine; Pfizer; Natural Sciences and Engineering Research Council of Canada; Takeda Canada; Canadian Institutes of Health Research; Innovative Medicines Initiative; Leukemia and Lymphoma Society of Canada; National Institutes of Health; Canada Foundation for Innovation; Ontario Ministry of Research, Innovation and Science; Wellcome Trust; Consejo Nacional de Ciencia y Tecnología; National Institute of Allergy and Infectious Diseases; National Center for Research Resources; AbbVie; Novartis Pharma; Ontario Genomics Institute; Genome Canada; Office of Science; Boehringer Ingelheim; Bayer; National Cancer Institute; Merck","keywords":"Biology; Recombination; DNA; Non-homologous end joining; Immunoglobulin class switching; Cell biology; Class (philosophy); Genetics; DNA repair; B cell; Gene; Antibody; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003347276,0.0003732626,0.0003226681,0.0004327829,0.0004397754,0.0008222453,0.0004296645,0.0005712057,0.004668199],"category_scores_gemma":[0.000270611,0.0002076733,0.0003594123,0.0002623674,0.0004574886,0.0009429371,0.0007003326,0.0009018935,0.001816876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007352074,"about_ca_system_score_gemma":0.0004370187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007689891,"about_ca_topic_score_gemma":0.0006687311,"domain_scores_codex":[0.999775,0.00003343095,0.00001181483,0.00005349271,0.00005533933,0.00007103657],"domain_scores_gemma":[0.9997187,0.00004471257,0.00003391323,0.00006306385,0.00004458776,0.00009488806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003638741,0.00001666645,0.001045653,0.0000369193,0.000007707219,0.0002341653,0.00003415978,0.0001229111,0.9936615,0.001624617,0.00008788647,0.002763867],"study_design_scores_gemma":[0.00001647248,0.00005102832,0.007332242,0.000005734607,0.000007808927,0.0003485225,0.00005766325,0.0009452633,0.987569,0.0002418029,0.003418501,0.000005882671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820218,0.002605657,0.009998883,0.0003063258,0.0001015737,0.0000222303,0.0007399706,0.0002312184,0.003972271],"genre_scores_gemma":[0.9870756,0.0004167435,0.003858517,0.00006988174,0.00002514877,0.00001427389,0.0007250447,0.00005410522,0.007760555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004668199,"threshold_uncertainty_score":0.01561671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004756061082385877,"score_gpt":0.1934685315347339,"score_spread":0.188712470452348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}