{"id":"W2999860983","doi":"10.1016/j.molcel.2019.10.031","title":"HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells","year":2019,"lang":"en","type":"article","venue":"Molecular Cell","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Structural Genomics Consortium; University of Toronto","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Janssen Pharmaceuticals; U.S. National Library of Medicine; Pfizer; Natural Sciences and Engineering Research Council of Canada; Takeda Canada; Canadian Institutes of Health Research; Innovative Medicines Initiative; Leukemia and Lymphoma Society of Canada; National Institutes of Health; Canada Foundation for Innovation; Ontario Ministry of Research, Innovation and Science; Wellcome Trust; Consejo Nacional de Ciencia y Tecnología; National Institute of Allergy and Infectious Diseases; National Center for Research Resources; AbbVie; Novartis Pharma; Ontario Genomics Institute; Genome Canada; Office of Science; Boehringer Ingelheim; Bayer; National Cancer Institute; Merck","keywords":"Biology; Recombination; DNA; Non-homologous end joining; Immunoglobulin class switching; Cell biology; Class (philosophy); Genetics; DNA repair; B cell; Gene; Antibody; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000415101,0.0001394906,0.0001309135,0.00007118849,0.00003762899,0.00001338435,0.0003250281,0.0001151922,0.00002015564],"category_scores_gemma":[0.00003465904,0.0001036623,0.0001510879,0.0002206522,0.00002934519,0.000006319379,0.000152061,0.0001751419,0.00001377712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003503176,"about_ca_system_score_gemma":0.00005243469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006150622,"about_ca_topic_score_gemma":0.00009376051,"domain_scores_codex":[0.9987046,0.0002652239,0.0002619638,0.0003409268,0.0002168775,0.0002104562],"domain_scores_gemma":[0.9992102,0.00002196105,0.0001424762,0.0005611145,0.00004440779,0.00001986948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002253857,0.00009999853,0.002119827,0.00003034493,0.00001292827,0.00000940557,0.0003441567,0.0009780404,0.9960588,0.0001687906,0.00002911046,0.0001260842],"study_design_scores_gemma":[0.000660584,0.0001237538,0.002149958,0.00003288238,0.000007756733,0.000003598463,0.0005215953,0.0005754605,0.9942927,0.0002032112,0.001306137,0.0001223488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909045,0.0001382397,0.0001586661,0.00009194959,0.0002894318,0.0004222784,0.000006637979,0.00001055262,0.007977756],"genre_scores_gemma":[0.9986277,0.00001402715,0.000155881,0.0001647882,0.00002109558,0.00003624398,0.00001790292,0.00002158713,0.0009407997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007723186,"threshold_uncertainty_score":0.4227226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004756061082385877,"score_gpt":0.1934685315347339,"score_spread":0.188712470452348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}