{"id":"W2999948479","doi":"10.1016/j.jmb.2020.01.012","title":"A Synthetic Human Antibody Antagonizes IL-18Rβ Signaling Through an Allosteric Mechanism","year":2020,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"ShanghaiTech University; National Natural Science Foundation of China","keywords":"Allosteric regulation; Mechanism (biology); Signal transduction; Antibody; MAPK/ERK pathway; Cytokine; Secretion; Immune system; Biology; Receptor; Immunology; Cell biology; Cancer research; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003826682,0.0003757965,0.0002694416,0.0001733715,0.0001570142,0.0002534935,0.0005620358,0.0003962544,0.003262209],"category_scores_gemma":[0.0002877226,0.00015752,0.0002605489,0.0001097119,0.0003707432,0.000190741,0.0002194128,0.0007935797,0.0006102787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002686016,"about_ca_system_score_gemma":0.0002526885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004198596,"about_ca_topic_score_gemma":0.0005529191,"domain_scores_codex":[0.9997905,0.0000459266,0.00001638104,0.00003651064,0.00005014873,0.00006057676],"domain_scores_gemma":[0.9998837,0.00003752468,0.00002534223,0.00001663344,0.00001290154,0.00002393581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006196207,0.0001531365,0.000208903,0.00008647917,0.0000209204,0.0001129541,0.00001956019,0.0001156992,0.9944225,0.001015961,0.0002494026,0.002974927],"study_design_scores_gemma":[0.0002966736,0.0008468929,0.0009305393,0.000009813987,0.00003460039,0.0005814956,0.00001567176,0.001204741,0.9905164,0.0002177653,0.005334824,0.00001043848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825208,0.001869693,0.008010043,0.000650027,0.0003193084,0.0001062469,0.0002237703,0.0002767039,0.006023414],"genre_scores_gemma":[0.9927318,0.0007253264,0.003699964,0.0002830396,0.00004942706,0.00004509892,0.0001714202,0.00002239882,0.002271624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003262209,"threshold_uncertainty_score":0.01091319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01528402133805517,"score_gpt":0.30179395660591,"score_spread":0.2865099352678548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}