{"id":"W3000007064","doi":"10.4049/jimmunol.1900531","title":"The VR23 Antitumor Compound Also Shows Strong Anti-Inflammatory Effects in a Human Rheumatoid Arthritis Cell Model and Acute Lung Inflammation in Mice","year":2020,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Laurentian University; Health Sciences North","funders":"","keywords":"Proinflammatory cytokine; Rheumatoid arthritis; Inflammation; Medicine; Downregulation and upregulation; Tumor necrosis factor alpha; Proteasome inhibitor; Immunology; Pharmacology; Arthritis; Proteasome; Bortezomib; Monocyte; Dexamethasone; Cancer research; Internal medicine; Chemistry; Multiple myeloma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001066243,0.0005026746,0.0005094388,0.0004425421,0.0001752838,0.0002245591,0.0002143463,0.0003481544,0.002532782],"category_scores_gemma":[0.00009323151,0.0001002627,0.000404774,0.0003137642,0.0001532336,0.0001626709,0.00009972632,0.0007350084,0.0005423282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001475561,"about_ca_system_score_gemma":0.0002201535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009694166,"about_ca_topic_score_gemma":0.001421302,"domain_scores_codex":[0.9998717,0.00002672858,0.000008799226,0.0000220957,0.00003271074,0.00003790136],"domain_scores_gemma":[0.9999332,0.000008104962,0.00001783426,0.000009153164,0.000009961511,0.00002162453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003197544,0.000161856,0.000103432,0.0001608208,0.00003759475,0.0001850064,0.00001353322,0.0002634129,0.9905258,0.00009700369,0.0002906126,0.007841097],"study_design_scores_gemma":[0.0001713234,0.004482463,0.003329753,0.00001505982,0.0000828386,0.001282477,0.00002456528,0.0005409227,0.9768438,0.00007073117,0.01313625,0.00001993724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.956553,0.02831982,0.006324781,0.0004351473,0.0001879936,0.0001180701,0.002164027,0.0004364385,0.00546069],"genre_scores_gemma":[0.9882344,0.00500436,0.002625926,0.0001104323,0.00004782769,0.00005654417,0.001229812,0.00002857551,0.002662216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002532782,"threshold_uncertainty_score":0.008472979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007476122549023046,"score_gpt":0.2255772031179844,"score_spread":0.2181010805689614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}