{"id":"W3000018687","doi":"10.1016/j.clgc.2019.12.018","title":"Plasma Circulating Tumor DNA and Clonal Hematopoiesis in Metastatic Renal Cell Carcinoma","year":2020,"lang":"en","type":"article","venue":"Clinical Genitourinary Cancer","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Pfizer Canada; EMD Serono; Eisai; Bayer Canada; Bayer; Ipsen Biopharmaceuticals; Astellas Pharma Canada; AstraZeneca Canada; Janssen Canada; Sanofi; Bristol-Myers Squibb; AstraZeneca; Pfizer; Janssen Biotech; Canadian Institutes of Health Research; ESSA Pharma; BC Cancer Foundation; Roche; Astellas Pharma US","keywords":"Renal cell carcinoma; Medicine; BAP1; Somatic cell; Liquid biopsy; Cell-free fetal DNA; Germline; Oncology; Concordance; Germline mutation; Cancer research; Cancer; Internal medicine; Gene; Mutation; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003347803,0.0001630107,0.0002105909,0.001252441,0.0002877479,0.0004833807,0.0003145,0.0005818213,0.002550245],"category_scores_gemma":[0.002463014,0.0001863801,0.00008237814,0.0007061727,0.0003167825,0.0003439968,0.0002372267,0.0004256938,0.0002102107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003215821,"about_ca_system_score_gemma":0.000261263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001312041,"about_ca_topic_score_gemma":0.001277692,"domain_scores_codex":[0.9998326,0.00003790147,0.00001494692,0.00002885323,0.00005203532,0.000033579],"domain_scores_gemma":[0.9989877,0.0005432859,0.0001676122,0.00004361815,0.00008784436,0.0001698739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002361113,0.0001744064,0.9210192,0.00007550533,0.00004941566,0.008415801,0.0005761268,0.0004221015,0.04355551,0.0004304383,0.0004948439,0.02242558],"study_design_scores_gemma":[0.00004315046,0.0005669553,0.9683132,0.00001807528,0.00005603557,0.01926334,0.0004674539,0.001929801,0.007674736,0.000504051,0.001150964,0.00001214345],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979284,0.0005721737,0.0001970287,0.00007840556,0.000009224007,0.00000433155,0.00008163469,0.00001423195,0.001114546],"genre_scores_gemma":[0.9994453,0.00008157808,0.0001167952,0.00002948266,0.00002058496,0.000002674503,0.00005269629,0.000003510663,0.0002473287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002550245,"threshold_uncertainty_score":0.008531392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04243167238192352,"score_gpt":0.3125762196046652,"score_spread":0.2701445472227417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}