{"id":"W3000018687","doi":"10.1016/j.clgc.2019.12.018","title":"Plasma Circulating Tumor DNA and Clonal Hematopoiesis in Metastatic Renal Cell Carcinoma","year":2020,"lang":"en","type":"article","venue":"Clinical Genitourinary Cancer","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Pfizer Canada; EMD Serono; Eisai; Bayer Canada; Bayer; Ipsen Biopharmaceuticals; Astellas Pharma Canada; AstraZeneca Canada; Janssen Canada; Sanofi; Bristol-Myers Squibb; AstraZeneca; Pfizer; Janssen Biotech; Canadian Institutes of Health Research; ESSA Pharma; BC Cancer Foundation; Roche; Astellas Pharma US","keywords":"Renal cell carcinoma; Medicine; BAP1; Somatic cell; Liquid biopsy; Cell-free fetal DNA; Germline; Oncology; Concordance; Germline mutation; Cancer research; Cancer; Internal medicine; Gene; Mutation; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001766546,0.0001848554,0.0003067024,0.00002555409,0.00005495427,0.00002527348,0.0001564344,0.00008951663,0.00005163117],"category_scores_gemma":[0.0002126882,0.0001914098,0.0001282761,0.0001003559,0.0001114847,0.000004571865,0.0002419689,0.0002048748,0.000008008132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002196773,"about_ca_system_score_gemma":0.0002624527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004793623,"about_ca_topic_score_gemma":0.00005467356,"domain_scores_codex":[0.9984735,0.00008273747,0.0005198385,0.0005342269,0.0001120864,0.0002776186],"domain_scores_gemma":[0.9992377,0.0001301234,0.000136556,0.0001953538,0.00004363941,0.000256637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002071807,0.000717563,0.5122612,0.0006327577,0.0002289468,0.001508287,0.0006038728,0.003007936,0.437497,0.00008783769,0.0217511,0.01963175],"study_design_scores_gemma":[0.02137174,0.006704094,0.4284873,0.0002164326,0.0005836067,0.0003126918,0.001248787,0.01610149,0.3751632,0.0007344578,0.1455907,0.003485551],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954232,0.002836809,0.00005790181,0.0006839686,0.0002350597,0.000180865,0.00007923598,0.000007816487,0.0004951574],"genre_scores_gemma":[0.9951711,0.0005575286,0.0009234163,0.002100303,0.001086881,0.00004222812,0.00003280945,0.00003120055,0.00005450438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1238396,"threshold_uncertainty_score":0.7805464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04243167238192352,"score_gpt":0.3125762196046652,"score_spread":0.2701445472227417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}