{"id":"W3000075574","doi":"10.1101/2020.01.10.893024","title":"Population sequencing data reveal a compendium of mutational processes in human germline","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Biology; Genetics; Germline; Human genome; Mutation rate; Compendium; Genome; Replication timing; Computational biology; Population; DNA replication; DNA sequencing; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001287074,0.0002660369,0.0004380573,0.001324137,0.0003070567,0.0007641201,0.0002751647,0.0003990097,0.001354769],"category_scores_gemma":[0.003997281,0.0002625526,0.0004853558,0.001507007,0.0002296273,0.0003053774,0.0005092072,0.0006468657,0.0007435012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002347313,"about_ca_system_score_gemma":0.0005208572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001325324,"about_ca_topic_score_gemma":0.003658224,"domain_scores_codex":[0.999069,0.0001289574,0.000071779,0.0004519466,0.0002283307,0.00004995104],"domain_scores_gemma":[0.9972224,0.001483288,0.0003269466,0.0005204527,0.0003218947,0.0001250174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005096218,0.0001282526,0.4190942,0.001058537,0.001370533,0.0007780949,0.00109729,0.01845513,0.3365935,0.006962387,0.01615483,0.1977977],"study_design_scores_gemma":[0.0000641335,0.0001468169,0.8858742,0.0000703406,0.0003657142,0.001624679,0.0001763612,0.02750548,0.02965533,0.01332378,0.04111122,0.00008192964],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.851622,0.002771837,0.07014865,0.0003243353,0.00004809791,0.00005743718,0.0710082,0.001156793,0.002862546],"genre_scores_gemma":[0.8473269,0.001210037,0.0353619,0.0002202948,0.00005304221,0.0001183063,0.1139664,0.0003713462,0.00137171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001354769,"threshold_uncertainty_score":0.006806791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03241087101469772,"score_gpt":0.2701406085669683,"score_spread":0.2377297375522705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}