{"id":"W3000182019","doi":"10.1016/j.neuroscience.2020.01.011","title":"Inhibition of 5α Reductase Impairs Cognitive Performance, Alters Dendritic Morphology and Increases Tau Phosphorylation in the Hippocampus of Male 3xTg-AD Mice","year":2020,"lang":"en","type":"article","venue":"Neuroscience","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Kellogg's (Canada); University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Finasteride; Dendritic spine; Hippocampal formation; Hippocampus; Neuroprotection; Neuroactive steroid; Internal medicine; Endocrinology; Testosterone (patch); Medicine; Neuroscience; Chemistry; Biology; Prostate; Receptor; GABAA receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002748909,0.001680406,0.001016737,0.002570611,0.0006535022,0.0008415884,0.0008517883,0.001342453,0.003971625],"category_scores_gemma":[0.0001942784,0.00065181,0.000993564,0.0008178381,0.001383628,0.0008742998,0.00045988,0.002604892,0.001216151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009997793,"about_ca_system_score_gemma":0.0006344676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007821134,"about_ca_topic_score_gemma":0.008931955,"domain_scores_codex":[0.9994882,0.00003261473,0.00005673142,0.0001424648,0.0001229297,0.0001570433],"domain_scores_gemma":[0.9992561,0.00004389873,0.0002972759,0.00006234558,0.00006092487,0.0002795156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001927335,0.0003117141,0.0005546898,0.00004719744,0.00003552397,0.0003006282,0.0001045892,0.00007360098,0.994803,0.0001763339,0.0001957233,0.001469556],"study_design_scores_gemma":[0.0001473236,0.001299277,0.02346307,0.00003011779,0.0001583997,0.0008103549,0.000367025,0.0007795895,0.9705727,0.0003463973,0.001974345,0.00005158124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909694,0.0009762357,0.001908635,0.0004935559,0.0001535833,0.00003239299,0.00372284,0.0003627135,0.00138074],"genre_scores_gemma":[0.9695692,0.001875454,0.003204355,0.0003640528,0.00006819675,0.0001643063,0.003517631,0.0004296546,0.0208071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007821134,"threshold_uncertainty_score":0.01555121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04284974764592576,"score_gpt":0.3096732620314465,"score_spread":0.2668235143855208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}