{"id":"W3000185208","doi":"10.1126/sciadv.aay6324","title":"Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":210,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Calgary; University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Children's Hospital Research Institute; Alberta Heritage Foundation for Medical Research; Multiple Sclerosis Society of Canada; University of Alberta","keywords":"Microglia; Macrophage; Lesion; Immune system; Inflammation; Central nervous system; Neuroscience; Biology; Medicine; Immunology; Pathology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003284729,0.0001509357,0.0001219114,0.0001126741,0.0007915528,0.000269436,0.0003210185,0.00002820454,0.00002420714],"category_scores_gemma":[0.001108285,0.0001400232,0.00004890308,0.0007854057,0.0002150615,0.001532224,0.00009821868,0.0001156427,0.00005416984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002067907,"about_ca_system_score_gemma":0.00006181948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":2.74171e-7,"about_ca_topic_score_gemma":6.455297e-7,"domain_scores_codex":[0.9980748,0.0001347368,0.0002413423,0.000717355,0.0005385791,0.0002931994],"domain_scores_gemma":[0.9993103,0.0001530325,0.0001242386,0.0001549835,0.00004146111,0.0002160295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006938292,0.000005961016,0.00003644783,0.000005000718,5.917599e-7,0.00004706765,0.000615846,0.0001648569,0.9923955,0.0001349717,0.00001255616,0.006511844],"study_design_scores_gemma":[0.0002337349,0.0001511137,0.00006579592,0.000009141,0.000006040644,0.00004085878,0.00005869083,0.007650713,0.9899073,0.0001246126,0.001602275,0.0001496734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928531,0.0001134992,0.001658703,0.004606703,0.0003412618,0.0002068047,0.00001044291,0.0001316135,0.0000778569],"genre_scores_gemma":[0.9904338,0.00009331827,0.002033151,0.007226943,0.00004476227,0.000007306763,5.82915e-7,0.00001270732,0.0001474237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007485856,"threshold_uncertainty_score":0.6088064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.027231734506389,"score_gpt":0.2937675736779877,"score_spread":0.2665358391715987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}