{"id":"W3000225091","doi":"10.1038/s41420-019-0235-x","title":"BORIS/CTCFL promotes a switch from a proliferative towards an invasive phenotype in melanoma cells","year":2020,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; McGill University; Israel Cancer Research Fund","keywords":"Reprogramming; Melanoma; Phenotype; Biology; Phenotypic switching; Cancer research; Transcriptome; Regulator; Cell biology; Gene expression; Genetics; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005156766,0.0001606132,0.0001223282,0.000131134,0.0001014061,0.0001721448,0.00007326057,0.0001203935,0.001754093],"category_scores_gemma":[0.00003455244,0.00009593157,0.0001158922,0.00008074026,0.0001197812,0.00007381209,0.0001328707,0.0003299885,0.0002990915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001724255,"about_ca_system_score_gemma":0.00008874974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004973059,"about_ca_topic_score_gemma":0.000758567,"domain_scores_codex":[0.9999332,0.000007269421,0.00000410908,0.00001559269,0.00001903492,0.00002077425],"domain_scores_gemma":[0.9999568,0.000007624391,0.00001056206,0.000004995317,0.000004092818,0.00001583098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001825157,0.000005017128,0.00005939677,0.000005305227,6.682083e-7,0.00001196852,0.000002941258,0.00001049727,0.9996779,0.00002517285,0.00001194984,0.0001710197],"study_design_scores_gemma":[0.000007629559,0.000110202,0.005357032,0.000002195319,0.000003987792,0.00008683446,0.00002850562,0.0008100159,0.9921245,0.00003916755,0.001427295,0.000002545274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955134,0.0004845859,0.001922752,0.00006205907,0.00002456712,0.00001240204,0.0003944052,0.0001077888,0.001478116],"genre_scores_gemma":[0.995881,0.000199717,0.0007477566,0.00003908705,0.000004133365,0.00001186306,0.0003852224,0.00001623856,0.002715097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001754093,"threshold_uncertainty_score":0.005868077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01643855177294048,"score_gpt":0.2331069639593702,"score_spread":0.2166684121864297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}