{"id":"W3000236443","doi":"10.1128/jvi.01999-19","title":"HIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4 <sup>+</sup> T Cells","year":2020,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Fonds de Recherche du Québec - Santé; Wellcome; Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs; Government of Canada; Deutsche Forschungsgemeinschaft; amfAR, The Foundation for AIDS Research; Western University; Canada Foundation for Innovation; Wellcome Trust","keywords":"Biology; Transmembrane protein; Viral replication; Virology; Transmembrane domain; Subcellular localization; Cell biology; Human immunodeficiency virus (HIV); Surface protein; Molecular biology; Virus; Genetics; Receptor; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002637957,0.000178326,0.0005983428,0.00004171392,0.00008076632,0.000006227575,0.0004698887,0.0003836705,0.002017397],"category_scores_gemma":[0.0001261521,0.0001132422,0.0002096785,0.0001521628,0.0004171689,0.00005195597,0.0001124522,0.0006613718,0.0002148185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001926613,"about_ca_system_score_gemma":0.0001109241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000890954,"about_ca_topic_score_gemma":0.00001237261,"domain_scores_codex":[0.998291,0.0005462833,0.0006308543,0.0001906535,0.00004128591,0.0002999511],"domain_scores_gemma":[0.9984326,0.000565443,0.0005957777,0.0002054409,0.0001582336,0.00004251008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007912852,0.00008534186,0.01694708,0.000006273807,0.0004938357,0.00001342279,0.001184572,0.00185483,0.9509313,0.00007195793,0.02676923,0.0008509071],"study_design_scores_gemma":[0.006998859,0.005370487,0.1181046,0.00004852599,0.0005589834,0.0005726752,0.001089689,0.0002391871,0.5735675,0.0008057437,0.2921948,0.0004489748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876239,0.004490941,0.0001746592,0.006847173,0.0004687023,0.00009107809,0.0000806985,0.00001418962,0.0002086728],"genre_scores_gemma":[0.9972962,0.000361867,0.0001423584,0.001843157,0.0001962883,8.97044e-7,0.00002371801,0.00001416826,0.0001213265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3773637,"threshold_uncertainty_score":0.9988949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009334255355690504,"score_gpt":0.207184484215287,"score_spread":0.1978502288595965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}