{"id":"W3000240575","doi":"10.3233/jad-190773","title":"Reduced Hippocampal Glutamate and Posterior Cingulate N-Acetyl Aspartate in Mild Cognitive Impairment and Alzheimer’s Disease Is Associated with Episodic Memory Performance and White Matter Integrity in the Cingulum: A Pilot Study","year":2020,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Parkwood Institute; Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"Cingulum (brain); Posterior cingulate; White matter; Episodic memory; Neuroscience; Cognitive impairment; Hippocampal formation; Psychology; Alzheimer's disease; Glutamate receptor; Dementia; Cognition; Memory impairment; Hippocampus; Medicine; Disease; Audiology; Internal medicine; Magnetic resonance imaging; Fractional anisotropy; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006792381,0.0004575953,0.0007665073,0.0002787113,0.0001618044,0.000143814,0.0001372772,0.00004508868,0.00006245353],"category_scores_gemma":[0.0001080155,0.0002977637,0.00009164802,0.0003984129,0.0003079672,0.0004487783,0.0001384904,0.0007003882,0.000007525626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005395711,"about_ca_system_score_gemma":0.0004552832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005993626,"about_ca_topic_score_gemma":0.00002283811,"domain_scores_codex":[0.9968781,0.0005065922,0.0007204743,0.0005251641,0.0008066599,0.0005630162],"domain_scores_gemma":[0.997375,0.0001336566,0.0003840444,0.0002285177,0.0002311004,0.00164772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02332334,0.002779461,0.9576815,0.000100585,0.005653381,0.004071931,0.00535772,0.000003641166,0.00002007574,2.193576e-7,0.0002007075,0.0008074181],"study_design_scores_gemma":[0.01458872,0.006916078,0.9661191,0.001025836,0.007549637,0.0001224727,0.00279461,0.0005277285,0.00004157787,0.00002148864,0.000001183436,0.0002915638],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743473,0.01670097,3.685291e-7,0.006826989,0.0000304164,0.001941249,0.0001117933,0.00001485891,0.00002609133],"genre_scores_gemma":[0.9970075,0.0004084159,0.00002256994,0.002347195,0.00006676385,0.00007239677,0.00002280325,0.00004831099,0.000003985843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02266029,"threshold_uncertainty_score":0.9999474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04818419416415638,"score_gpt":0.3091704084277133,"score_spread":0.2609862142635569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}