{"id":"W3000240575","doi":"10.3233/jad-190773","title":"Reduced Hippocampal Glutamate and Posterior Cingulate N-Acetyl Aspartate in Mild Cognitive Impairment and Alzheimer’s Disease Is Associated with Episodic Memory Performance and White Matter Integrity in the Cingulum: A Pilot Study","year":2020,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Parkwood Institute; Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"Cingulum (brain); Posterior cingulate; White matter; Episodic memory; Neuroscience; Cognitive impairment; Hippocampal formation; Psychology; Alzheimer's disease; Glutamate receptor; Dementia; Cognition; Memory impairment; Hippocampus; Medicine; Disease; Audiology; Internal medicine; Magnetic resonance imaging; Fractional anisotropy; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002302517,0.0003615423,0.000246507,0.0005453424,0.0004833738,0.0002566289,0.0001587783,0.0002674624,0.001049711],"category_scores_gemma":[0.0007005165,0.0001775695,0.0001652213,0.000168899,0.0003210586,0.0001907093,0.0002556576,0.0001848003,0.0001142788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002159871,"about_ca_system_score_gemma":0.0001457304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004821709,"about_ca_topic_score_gemma":0.009537037,"domain_scores_codex":[0.9999123,0.00001593899,0.00001004507,0.00001992966,0.00001647496,0.00002542798],"domain_scores_gemma":[0.9997551,0.00002705094,0.00007698515,0.00002396311,0.00003824454,0.00007866963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002771221,0.0004528084,0.9753097,0.00002727244,0.0001336427,0.001292176,0.0005551291,0.00007970993,0.01341832,0.00002969237,0.0001251768,0.005805053],"study_design_scores_gemma":[0.00001521764,0.0003651346,0.9985292,0.00000158221,0.0000169034,0.0005681438,0.00008935916,0.00005235738,0.0002975669,0.00001621353,0.00004672848,0.000001498922],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9998705,0.00002170694,0.00001137504,0.000003742278,8.263871e-7,0.000003217261,0.00001296629,4.827385e-7,0.00007504741],"genre_scores_gemma":[0.9998446,0.0000109128,0.00002990054,0.000005780254,0.00000211888,0.000002387172,0.00002630108,3.624492e-7,0.0000775342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004821709,"threshold_uncertainty_score":0.009587288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04818419416415638,"score_gpt":0.3091704084277133,"score_spread":0.2609862142635569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}