{"id":"W3000286044","doi":"10.6004/jnccn.2019.7345","title":"Response Rates and Durations of Response for Biomarker-Based Cancer Drugs in Nonrandomized Versus Randomized Trials","year":2020,"lang":"en","type":"review","venue":"Journal of the National Comprehensive Cancer Network","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Medicine; Randomized controlled trial; Relative risk; Meta-analysis; Pharmacogenomics; Confidence interval; Biomarker; Internal medicine; Oncology; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.0415155,0.0004987288,0.009980232,0.0003351573,0.0001285551,0.00005291049,0.0005874547,0.0003879302,0.0001009115],"category_scores_gemma":[0.5311278,0.0002950398,0.002929257,0.0009042855,0.0004673049,0.00006258168,0.0001154643,0.0007308991,4.679806e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005598274,"about_ca_system_score_gemma":0.003601569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005809043,"about_ca_topic_score_gemma":0.000005334677,"domain_scores_codex":[0.9443724,0.0473782,0.006486718,0.0003791919,0.001078775,0.000304698],"domain_scores_gemma":[0.4695828,0.5222962,0.006110841,0.0001529814,0.001755193,0.0001019152],"domain_codex":null,"domain_gemma":"methods","domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.946116,0.00008794915,5.917685e-7,0.002244124,0.002760113,0.000003088045,0.00006946252,0.0005849783,0.00001873241,0.001220821,0.01263961,0.03425448],"study_design_scores_gemma":[0.4669787,0.0003776531,0.00001813173,0.02831955,0.009396908,0.000010073,0.00003291634,0.001674497,0.00002602574,0.1408034,0.3518288,0.0005334007],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001297193,0.9796828,0.005194827,0.004418739,0.003912399,0.005399151,0.001244102,0.000009133162,0.000009152033],"genre_scores_gemma":[0.00008111091,0.8854734,0.1114866,0.0003829212,0.001498175,0.0009518604,0.000003981115,0.00008004174,0.00004193989],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4896123,"threshold_uncertainty_score":0.9999502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7160078237002326,"score_gpt":0.6306847045581461,"score_spread":0.08532311914208657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}