{"id":"W3000294122","doi":"10.3390/cancers12010172","title":"Triple-Negative Primary Breast Tumors Induce Supportive Premetastatic Changes in the Extracellular Matrix and Soluble Components of the Lung Microenvironment","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; London Health Sciences Centre; Western University","funders":"London Health Sciences Foundation; Breast Cancer Society of Canada; Canadian Cancer Society Research Institute; Ontario Council on Graduate Studies, Council of Ontario Universities; Cancer Research Society","keywords":"Tumor microenvironment; Cancer research; Breast cancer; Extracellular matrix; Metastasis; Triple-negative breast cancer; Medicine; Primary tumor; Fibronectin; Tumor progression; Immunology; Pathology; Biology; Cancer; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001066057,0.0002808365,0.0002372445,0.0002268744,0.0001276416,0.0002979761,0.0000751557,0.000206794,0.00202831],"category_scores_gemma":[0.0001024687,0.000152549,0.000208517,0.0000842656,0.0001583504,0.0001140865,0.0002280359,0.0005343764,0.0003365034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002378606,"about_ca_system_score_gemma":0.0002261058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006617614,"about_ca_topic_score_gemma":0.001739493,"domain_scores_codex":[0.9998449,0.0000142771,0.000009764435,0.00002051997,0.0000620643,0.0000484214],"domain_scores_gemma":[0.999877,0.00001612123,0.00002857088,0.000009088068,0.000011267,0.00005789697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007148357,0.00002338447,0.000258568,0.00001537522,0.000002724218,0.00007390718,0.000009849949,0.00001059787,0.9991178,0.00002379036,0.0000366538,0.0003558902],"study_design_scores_gemma":[0.00003626808,0.001697949,0.02932118,0.00001505397,0.00002577277,0.001410279,0.0001494987,0.0005735101,0.9638361,0.00008048068,0.002847017,0.000006883979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971042,0.0005101123,0.0003073438,0.00006143677,0.00001718364,0.00002331192,0.0002315172,0.00002864051,0.001716173],"genre_scores_gemma":[0.9964019,0.0002858001,0.0003908913,0.00006975204,0.000006239138,0.00002987096,0.0004046026,0.000007782421,0.002403208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00202831,"threshold_uncertainty_score":0.006785393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277346781062789,"score_gpt":0.2357133759373634,"score_spread":0.2229399081267355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}