{"id":"W3000309104","doi":"10.1016/j.pnpbp.2020.109867","title":"Validation study of microRNAs previously associated with antidepressant response in older adults treated for late-life depression with venlafaxine","year":2020,"lang":"en","type":"article","venue":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; McGill University; Douglas Mental Health University Institute; Centre for Addiction and Mental Health; McMaster University; University Health Network; University of Toronto","funders":"Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine in St. Louis; Janssen Biotech; Centre for Addiction and Mental Health Foundation; Canadian Institutes of Health Research; Alkermes; Patient-Centered Outcomes Research Institute; H. Lundbeck A/S; Centre for Addiction and Mental Health; Department of Psychiatry, University of Toronto; Pfizer; Fondation Brain Canada; University of Pittsburgh; Health Research","keywords":"Venlafaxine; Antidepressant; Depression (economics); Late life depression; Medicine; Psychology; Psychiatry; Anxiety; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005014887,0.0002573245,0.0005567348,0.0003021286,0.0002888702,0.0005764345,0.0002109714,0.0004056148,0.0007798367],"category_scores_gemma":[0.001476538,0.000140724,0.0003271221,0.0004396409,0.0001523946,0.0001332441,0.0001640839,0.0003116971,0.0001708638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003093091,"about_ca_system_score_gemma":0.0002495516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001300632,"about_ca_topic_score_gemma":0.002048492,"domain_scores_codex":[0.9995623,0.0001052464,0.00005946953,0.0001541536,0.00007801862,0.00004079652],"domain_scores_gemma":[0.999374,0.0002053952,0.0002094017,0.00004324931,0.0001225718,0.00004533724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006417706,0.0003175049,0.9124407,0.0001900632,0.0006986217,0.0003996568,0.0004337278,0.0002886467,0.05515523,0.0001426795,0.0007478555,0.0227677],"study_design_scores_gemma":[0.0001681963,0.0009789395,0.9877215,0.00002955947,0.0004344316,0.0007353185,0.000190691,0.0008376696,0.006845162,0.00005171991,0.001992778,0.00001407137],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980224,0.0005059742,0.0003023303,0.00003747934,0.00002005558,0.00002951915,0.0006769902,0.000006818637,0.0003984066],"genre_scores_gemma":[0.9979028,0.0001437407,0.0006239527,0.0001267564,0.00001338487,0.00006581833,0.0006484827,0.000006035618,0.0004690236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001300632,"threshold_uncertainty_score":0.002652109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01462156402516707,"score_gpt":0.2893202300533378,"score_spread":0.2746986660281707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}