{"id":"W3000313970","doi":"10.1038/s41467-019-14159-1","title":"Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":347,"is_retracted":false,"has_abstract":true,"ca_institutions":"St Joseph's Health Care; St Joseph's Health Centre; Sunnybrook Health Science Centre","funders":"National Center for Advancing Translational Sciences; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Alzheimer Forschung Initiative; F. Hoffmann-La Roche; Biogen; BioClinica; European Commission; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Alzheimer's disease; Disease; Neuroscience; Medicine; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004080715,0.0002661684,0.0002009426,0.0008243521,0.0001834619,0.0003377361,0.0001530627,0.0002855879,0.0009430817],"category_scores_gemma":[0.001985481,0.0001328115,0.00022235,0.0004308271,0.000247001,0.0003492253,0.0002571104,0.0002555163,0.0001167744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001772423,"about_ca_system_score_gemma":0.00007663709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001471886,"about_ca_topic_score_gemma":0.001901949,"domain_scores_codex":[0.9998554,0.00004215499,0.00001286948,0.00004935859,0.00002316207,0.00001709911],"domain_scores_gemma":[0.9992381,0.0002094562,0.0003363352,0.00009784299,0.0000545233,0.00006367341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008242787,0.000095166,0.9391246,0.00004417226,0.000426961,0.0003650774,0.0002740722,0.001966202,0.04056422,0.0005346766,0.0003186408,0.01546203],"study_design_scores_gemma":[0.000002186266,0.00005884204,0.997632,0.000002100719,0.00002257622,0.0002879553,0.00002071709,0.0009991423,0.000583743,0.0003231396,0.00006440427,0.000003094375],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986759,0.0001386731,0.0006463699,0.0000269818,0.000001786388,0.000002961671,0.0001362515,0.00001458496,0.0003563937],"genre_scores_gemma":[0.9992501,0.00006941525,0.0003349854,0.000005231553,0.00000447536,0.000004646267,0.0002255502,0.000004664524,0.0001008213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001471886,"threshold_uncertainty_score":0.003154993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1121587116167962,"score_gpt":0.3291055004185949,"score_spread":0.2169467888017986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}