{"id":"W3000319497","doi":"10.29173/hsi198","title":"Mitochondrial Replacement Therapy: Modifying Genes to Prevent Inherited Mitochondrial Disease","year":2019,"lang":"en","type":"article","venue":"Health Science Inquiry","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Mitochondrial DNA; Mitochondrial disease; Genetic enhancement; Mitochondrion; Gene; Genetics; Biology; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005069603,0.000244836,0.000255822,0.0001852239,0.0003372018,0.00008401616,0.0005112034,0.0001140337,0.0001943093],"category_scores_gemma":[0.000147036,0.0002242792,0.0001078999,0.0004858915,0.0002390494,0.00002060036,0.0002657117,0.0001354424,0.0002390711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001021324,"about_ca_system_score_gemma":0.001261846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004294868,"about_ca_topic_score_gemma":0.00001698727,"domain_scores_codex":[0.9969753,0.0001249876,0.0004615241,0.001115586,0.0005147138,0.0008079028],"domain_scores_gemma":[0.9979164,0.00001310559,0.0001645324,0.0009403477,0.0001592164,0.0008064106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001853036,0.0001975358,0.002541173,0.00003835355,0.00001101851,0.000002719601,0.0004994137,0.0005136071,0.9741805,0.0001155217,0.01361923,0.006427961],"study_design_scores_gemma":[0.005478604,0.005786096,0.01272182,0.0001457183,0.00001403487,0.00004765641,0.0006934021,0.0006080384,0.1559109,0.0001477048,0.8171897,0.001256333],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978294,0.0009026215,0.003688183,0.00168094,0.01333098,0.00182212,0.00001598874,0.00004728494,0.0002179531],"genre_scores_gemma":[0.9354382,0.00119111,0.01882443,0.02581833,0.0105437,0.000689353,0.0002678592,0.0001206486,0.007106429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8182696,"threshold_uncertainty_score":0.9145841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05006447448575732,"score_gpt":0.3450967581399474,"score_spread":0.2950322836541901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}