{"id":"W3000319497","doi":"10.29173/hsi198","title":"Mitochondrial Replacement Therapy: Modifying Genes to Prevent Inherited Mitochondrial Disease","year":2019,"lang":"en","type":"article","venue":"Health Science Inquiry","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Mitochondrial DNA; Mitochondrial disease; Genetic enhancement; Mitochondrion; Gene; Genetics; Biology; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003829406,0.0003091069,0.0003544641,0.0003920343,0.0002081352,0.0003378298,0.0004833371,0.0007112138,0.003063076],"category_scores_gemma":[0.0005938607,0.00007027551,0.0002658592,0.0002422527,0.0002656983,0.0002018057,0.0001951102,0.0006899422,0.0004492296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004014183,"about_ca_system_score_gemma":0.0004519809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001564238,"about_ca_topic_score_gemma":0.00394589,"domain_scores_codex":[0.9998535,0.00004360369,0.00001216834,0.00002739433,0.00004089322,0.00002248912],"domain_scores_gemma":[0.9998525,0.00003828637,0.00004585133,0.000009827269,0.00002454781,0.00002891597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00434108,0.003326299,0.0122614,0.001681312,0.0006439582,0.003048958,0.0004035098,0.001112883,0.3278457,0.006117938,0.0191047,0.6201122],"study_design_scores_gemma":[0.00977965,0.0265706,0.1191382,0.002666622,0.003591273,0.01718268,0.001011964,0.005316251,0.3186987,0.01319423,0.4826447,0.0002050669],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7707899,0.138536,0.03501986,0.02858286,0.002731658,0.0007700091,0.001839884,0.001033058,0.0206968],"genre_scores_gemma":[0.9002584,0.05232574,0.02411542,0.004894129,0.0005250399,0.0002937626,0.0009138093,0.00007768768,0.01659608],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003063076,"threshold_uncertainty_score":0.01024705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05006447448575732,"score_gpt":0.3450967581399474,"score_spread":0.2950322836541901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}