{"id":"W3000323522","doi":"10.1158/2159-8290.cd-19-1209","title":"Characteristics and Outcome of <i>AKT1</i> E17K-Mutant Breast Cancer Defined through AACR Project GENIE, a Clinicogenomic Registry","year":2020,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; National Institutes of Health; Cancer Prevention and Research Institute of Texas; American Association for Cancer Research","keywords":"AKT1; Mutant; Cancer; Breast cancer; Outcome (game theory); Medicine; Computational biology; Bioinformatics; Oncology; Biology; Internal medicine; Genetics; Gene; Signal transduction; Mathematics; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009799439,0.0001266495,0.0002296656,0.0009447788,0.0002664794,0.0004713952,0.000304579,0.0001911426,0.001235586],"category_scores_gemma":[0.00184135,0.00008094494,0.0002026768,0.001452504,0.000226712,0.0002671342,0.0005313876,0.0002442878,0.0002325298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005005861,"about_ca_system_score_gemma":0.0004695323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004384126,"about_ca_topic_score_gemma":0.006290164,"domain_scores_codex":[0.9992084,0.0002295659,0.0001074258,0.0002176296,0.0001393551,0.0000975786],"domain_scores_gemma":[0.9980453,0.0002372389,0.00118618,0.0001983162,0.0001647403,0.0001681049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001856443,0.00002081243,0.9970788,0.000008922999,0.00003007749,0.00005420091,0.00003845672,0.0001467103,0.000433787,0.00006503911,0.0005685096,0.001369104],"study_design_scores_gemma":[0.00001951383,0.0001129499,0.997276,0.000006989173,0.00002453317,0.0004853787,0.0001558954,0.0005512674,0.0003325943,0.0000667417,0.0009618186,0.000006430388],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926722,0.00005914753,0.000291883,0.00004881475,0.000003039378,0.00002054236,0.006192367,0.000009648059,0.0007023943],"genre_scores_gemma":[0.9932855,0.0000271342,0.0001588562,0.00002708818,0.000004475796,0.00003770776,0.006340579,0.000005756191,0.0001128594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004384126,"threshold_uncertainty_score":0.008717239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02842900033929516,"score_gpt":0.2954283535175873,"score_spread":0.2669993531782921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}