{"id":"W3000342395","doi":"10.3390/cancers12010169","title":"Differential Depletion of Bone Marrow Resident B-ALL after Systemic Administration of Endosomal TLR Agonists","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Children's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Bone marrow; TLR9; Medicine; Immunology; Minimal residual disease; Agonist; Cancer research; Innate immune system; Immune system; Leukemia; Chemotherapy; Receptor; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006020435,0.0001136332,0.0003443464,0.00006346215,0.00001198629,0.000007024599,0.00007472066,0.00009123998,0.0003378803],"category_scores_gemma":[0.0001380726,0.0001029924,0.00009786314,0.0001360835,0.0001163077,0.0000453055,0.00004064844,0.0001202139,0.00001331396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001333558,"about_ca_system_score_gemma":0.001750272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002055606,"about_ca_topic_score_gemma":0.00003135105,"domain_scores_codex":[0.9986053,0.00004785956,0.0004178448,0.0002238344,0.0005075781,0.0001976128],"domain_scores_gemma":[0.9992701,0.00004872142,0.000164965,0.000198644,0.000133256,0.0001843477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01220389,0.00004119784,0.01113243,0.003379574,0.0002456014,0.0004036317,0.002255196,0.00008072743,0.9655969,0.0001183499,0.003776266,0.0007662183],"study_design_scores_gemma":[0.01733395,0.004720978,0.08021274,0.002295597,0.0007446923,0.0006078317,0.001585337,0.01366582,0.8765805,0.00003982699,0.001675536,0.0005372284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971432,0.0003075599,0.001019103,0.0006721641,0.0001194524,0.000394642,0.0000468974,0.00002318963,0.0002737648],"genre_scores_gemma":[0.9991373,0.00007158089,0.0001313845,0.0001565339,0.0002399506,0.00004671595,0.00004588189,0.00002037963,0.0001502396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08901646,"threshold_uncertainty_score":0.419991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02054669297118553,"score_gpt":0.2814667787789989,"score_spread":0.2609200858078133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}