{"id":"W3000348398","doi":"10.1101/2020.01.20.912592","title":"Glutamate dehydrogenase (Gdh2)-dependent alkalization is dispensable for escape from macrophages and virulence of <i>Candida albicans</i>","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Stockholms Universitet; Hospital for Sick Children; Julius-Maximilians-Universität Würzburg; Vetenskapsrådet","keywords":"Biochemistry; Candida albicans; Glutamate dehydrogenase; Biology; Amino acid; Corpus albicans; Virulence; Deamination; Cell biology; Chemistry; Microbiology; Glutamate receptor; Enzyme; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008950932,0.0003222177,0.0002616502,0.0001843701,0.0001541851,0.000544322,0.0004517852,0.0002510539,0.001125029],"category_scores_gemma":[0.0001698682,0.0001615178,0.000232601,0.0001695693,0.0002558671,0.0001223576,0.0004428599,0.0004839143,0.0004413516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004433163,"about_ca_system_score_gemma":0.0004267067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00265203,"about_ca_topic_score_gemma":0.00304945,"domain_scores_codex":[0.9998232,0.00002105575,0.00002088943,0.00003930316,0.00005268265,0.00004297487],"domain_scores_gemma":[0.9997564,0.00003043541,0.00006758911,0.00003727652,0.00002558152,0.00008269715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007960844,0.00001364748,0.0002699032,0.00001830575,0.000002520549,0.0000551085,0.000007444588,0.00002250166,0.9990023,0.00005513973,0.00004392066,0.0004297234],"study_design_scores_gemma":[0.00001435419,0.00008617704,0.01235308,0.00001066198,0.00001014102,0.0003946622,0.00007519808,0.001065439,0.9836625,0.00004588987,0.002271265,0.0000106759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963157,0.0005132945,0.001093729,0.00009443925,0.0000207106,0.00001458524,0.0009624708,0.00009369037,0.0008914554],"genre_scores_gemma":[0.9961987,0.0001641837,0.0009124482,0.00005443439,0.000006196475,0.00002119436,0.001102693,0.0000498677,0.001490321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00265203,"threshold_uncertainty_score":0.005273223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01589123106558875,"score_gpt":0.2431919685840395,"score_spread":0.2273007375184507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}