{"id":"W3000373527","doi":"10.1007/s13300-019-00749-1","title":"Impact of Switching from Twice-Daily Basal Insulin to Once-Daily Insulin Glargine 300 U/mL in People with Type 1 Diabetes on Basal–Bolus Insulin: Phase 4 OPTIMIZE Study","year":2020,"lang":"en","type":"article","venue":"Diabetes Therapy","topic":"Diabetes Management and Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Universitaire Ziekenhuizen Leuven, KU Leuven; Sanofi","keywords":"Insulin glargine; Medicine; Basal insulin; Insulin; Basal (medicine); Diabetes mellitus; Internal medicine; Endocrinology; Type 2 diabetes","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001718589,0.000926399,0.002315995,0.0003010262,0.0003194956,0.0009037352,0.0006687632,0.001183348,0.004390423],"category_scores_gemma":[0.002372445,0.0004113315,0.002679311,0.0002898495,0.0003860051,0.0007264138,0.0004411913,0.002147472,0.0004329675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006189278,"about_ca_system_score_gemma":0.0007806761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00120054,"about_ca_topic_score_gemma":0.001396969,"domain_scores_codex":[0.9991248,0.0004729955,0.00006418616,0.0001438575,0.00007442359,0.0001196804],"domain_scores_gemma":[0.9989206,0.0003997349,0.0002208103,0.00008186406,0.00007046551,0.0003066162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8531387,0.04469797,0.004676015,0.0008498368,0.002045599,0.00007807589,0.0001421417,0.0008737342,0.002883727,0.00006497314,0.0008358593,0.08971335],"study_design_scores_gemma":[0.6300406,0.3410101,0.02366684,0.0001163898,0.001554348,0.00008845142,0.00009764347,0.001635229,0.0007460314,0.0001538905,0.0008430202,0.00004739898],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968244,0.001086046,0.0001654691,0.0001859179,0.00008320847,0.0006256152,0.000280425,0.00004327193,0.0007056806],"genre_scores_gemma":[0.9945723,0.0008908696,0.001236861,0.0007462849,0.0001774412,0.001208036,0.0005010814,0.00001571125,0.0006513236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004390423,"threshold_uncertainty_score":0.01468742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03087325850078365,"score_gpt":0.3243906294112558,"score_spread":0.2935173709104722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}