{"id":"W3000373527","doi":"10.1007/s13300-019-00749-1","title":"Impact of Switching from Twice-Daily Basal Insulin to Once-Daily Insulin Glargine 300 U/mL in People with Type 1 Diabetes on Basal–Bolus Insulin: Phase 4 OPTIMIZE Study","year":2020,"lang":"en","type":"article","venue":"Diabetes Therapy","topic":"Diabetes Management and Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Universitaire Ziekenhuizen Leuven, KU Leuven; Sanofi","keywords":"Insulin glargine; Medicine; Basal insulin; Insulin; Basal (medicine); Diabetes mellitus; Internal medicine; Endocrinology; Type 2 diabetes","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008605834,0.0007680999,0.001699733,0.0007225531,0.0001190796,0.0001411671,0.0007358135,0.0002003389,0.0007179421],"category_scores_gemma":[0.0004644819,0.0005692096,0.0002812883,0.002789221,0.00009528662,0.0003231595,0.0002515523,0.0009365435,0.0001644496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002197517,"about_ca_system_score_gemma":0.000323704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002865449,"about_ca_topic_score_gemma":0.00005388249,"domain_scores_codex":[0.9950556,0.0003928571,0.0009436002,0.001138452,0.001237973,0.001231559],"domain_scores_gemma":[0.9970775,0.0006060241,0.0002916641,0.000952003,0.0003387637,0.0007340112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01425831,0.009691505,0.8324911,0.0001583076,0.002135685,0.0000893853,0.008053785,0.002481921,0.04014301,0.000005137451,0.001584295,0.08890758],"study_design_scores_gemma":[0.05276236,0.05081237,0.8673981,0.0006053277,0.0002035604,8.758349e-8,0.001046063,0.01579919,0.009614495,0.00006862951,0.0006685778,0.00102119],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917341,0.001842046,0.00002864575,0.002335997,0.0001746365,0.003189421,0.0001115116,0.0001738378,0.000409732],"genre_scores_gemma":[0.9943711,0.0003485728,0.0008338204,0.003343224,0.0004388627,0.000180644,0.0002190203,0.0001914701,0.00007328888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08788639,"threshold_uncertainty_score":0.9996759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03087325850078365,"score_gpt":0.3243906294112558,"score_spread":0.2935173709104722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}