{"id":"W3000386776","doi":"10.2147/ndt.s198774","title":"<p>Management of Treatment-Resistant Depression: Challenges and Strategies</p>","year":2020,"lang":"en","type":"review","venue":"Neuropsychiatric Disease and Treatment","topic":"Treatment of Major Depression","field":"Medicine","cited_by":424,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Medicine; Treatment-resistant depression; Electroconvulsive therapy; Antidepressant; Deep brain stimulation; Transcranial magnetic stimulation; Major depressive disorder; Vagus nerve stimulation; Modalities; Depression (economics); Brain stimulation; Bipolar disorder; Psychiatry; Psychotherapist; Intensive care medicine; Lithium (medication); Schizophrenia (object-oriented programming); Stimulation; Internal medicine; Psychology; Mood; Anxiety","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001301899,0.000699006,0.001415066,0.001817899,0.0002698383,0.001104911,0.0008736756,0.001281038,0.004222201],"category_scores_gemma":[0.0023989,0.0002275054,0.001157232,0.002053569,0.0003463225,0.001236838,0.0006356739,0.001215928,0.001105636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008827809,"about_ca_system_score_gemma":0.002443467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001983852,"about_ca_topic_score_gemma":0.004673078,"domain_scores_codex":[0.9995568,0.0001643161,0.00009393422,0.00005159723,0.0001052226,0.00002808808],"domain_scores_gemma":[0.998892,0.000728741,0.0001732013,0.00002070855,0.0001484399,0.00003677385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007296352,0.00003870557,0.0001568481,0.09895997,0.0003127902,0.0001177445,0.00006918688,0.000225611,0.0003447245,0.002478417,0.0206112,0.8766118],"study_design_scores_gemma":[0.0001051117,0.0002464722,0.002288678,0.1505004,0.001851847,0.001937428,0.0002655415,0.0003806519,0.0003401175,0.005330699,0.8367159,0.00003725765],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005822793,0.9986905,0.00009047437,0.0005915512,0.00009700283,0.00001012488,0.00001580884,0.000004598779,0.0004417064],"genre_scores_gemma":[0.0007817412,0.9981527,0.0003203136,0.0004181112,0.0001139307,0.00001532778,0.00002128443,0.0000014468,0.0001751328],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004222201,"threshold_uncertainty_score":0.01412469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03908239779449776,"score_gpt":0.3026464108822601,"score_spread":0.2635640130877624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}