{"id":"W3000411451","doi":"10.1158/1078-0432.ccr-19-3023","title":"Diverse <i>AR</i> Gene Rearrangements Mediate Resistance to Androgen Receptor Inhibitors in Metastatic Prostate Cancer","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Institutes of Health; Prostate Cancer Foundation of Australia; National Cancer Institute; National Institute for Health and Care Research; U.S. Department of Veterans Affairs","keywords":"Androgen receptor; Prostate cancer; Cancer research; Prostate; Cancer; Gene; Biology; Medicine; Oncology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002837774,0.0003046287,0.0008391415,0.0003301062,0.0001982216,0.00007307638,0.0004413502,0.0001510167,0.001289974],"category_scores_gemma":[0.001288624,0.0002438063,0.0001998577,0.002361626,0.0004975674,0.0001770006,0.0004830375,0.001394716,0.0005304652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007644653,"about_ca_system_score_gemma":0.001594841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009221166,"about_ca_topic_score_gemma":0.001623019,"domain_scores_codex":[0.9938547,0.0007408629,0.0009959213,0.001208208,0.001885018,0.001315266],"domain_scores_gemma":[0.9966109,0.0004629162,0.0001118877,0.0005146819,0.0006992396,0.001600385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02839221,0.0009590249,0.579851,0.00108739,0.0006614604,0.001313271,0.004432841,0.00004714753,0.01886035,0.00002140294,0.2996707,0.06470328],"study_design_scores_gemma":[0.03560887,0.004613705,0.08058766,0.002577989,0.0003000432,0.000003628185,0.002965623,0.0001683849,0.07756598,0.0002737667,0.794106,0.00122834],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9209989,0.01063429,0.000003404739,0.06301226,0.0004684721,0.00351566,0.0004727784,0.00007511185,0.0008191132],"genre_scores_gemma":[0.9330304,0.04450411,0.001020684,0.00562428,0.001934029,0.003343647,0.0001625702,0.0001631018,0.01021712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4992633,"threshold_uncertainty_score":0.999623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.268129450313452,"score_gpt":0.5093051652964752,"score_spread":0.2411757149830231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}