{"id":"W3000412534","doi":"10.1093/ecco-jcc/jjz203.668","title":"P540 GB004, a novel prolyl hydroxylase inhibitor for inflammatory bowel disease, leads to gut-targeted HIF-1α pathway engagement in a multiple-dose study in healthy subjects","year":2020,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Tolerability; Pharmacokinetics; Adverse effect; Discontinuation; Pharmacodynamics; Inflammatory bowel disease; Dosing; Pharmacology; Placebo; Hypoxia (environmental); Buccal administration; Internal medicine; Gastroenterology; Disease; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001733267,0.001100463,0.001498788,0.000405666,0.0005434298,0.0004523627,0.0004514236,0.001047116,0.002147618],"category_scores_gemma":[0.000648622,0.0005803746,0.0007739069,0.0003193211,0.000924275,0.0004057208,0.0003010072,0.001148396,0.000368365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004799078,"about_ca_system_score_gemma":0.0008474902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00202386,"about_ca_topic_score_gemma":0.003455794,"domain_scores_codex":[0.9993724,0.0003224937,0.00003453925,0.0001079151,0.0000719372,0.00009068754],"domain_scores_gemma":[0.9995474,0.00008328114,0.00008098339,0.00004328611,0.0000516641,0.0001933009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4334231,0.05515971,0.009175611,0.001068391,0.0007543258,0.0007320944,0.0004147255,0.0005732219,0.4611381,0.00009165107,0.0009494375,0.03651953],"study_design_scores_gemma":[0.05779761,0.8890144,0.033478,0.0000180361,0.0004458725,0.0003008756,0.0001003263,0.0003960173,0.01733579,0.00004251241,0.001044344,0.00002623864],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977366,0.0007019916,0.0004298719,0.00006461319,0.00003184635,0.0005528675,0.0001542553,0.00003258226,0.0002953729],"genre_scores_gemma":[0.9958515,0.000561593,0.001020809,0.0001961641,0.00008523274,0.0005597923,0.0002445164,0.000009769209,0.001470463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002147618,"threshold_uncertainty_score":0.009166539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01896546242574116,"score_gpt":0.2638351789791271,"score_spread":0.244869716553386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}