{"id":"W3000433276","doi":"10.1093/ecco-jcc/jjz203.112","title":"DOP73 Efficacy and safety of escalation to tofacitinib 10 mg BID for patients with UC following loss of response on 5 mg BID maintenance therapy: Results from OCTAVE open-label, long-term extension study","year":2020,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"","keywords":"Tofacitinib; Medicine; Maintenance therapy; Octave (electronics); Open label; Internal medicine; Adverse effect; Surgery; Gastroenterology; Chemotherapy; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001474542,0.0004486649,0.001217416,0.0004232506,0.0002473819,0.001203574,0.0005336496,0.0006174713,0.002993038],"category_scores_gemma":[0.001904445,0.0002009325,0.00127925,0.0005104595,0.0003804621,0.0007030237,0.0003828517,0.001621924,0.0007216333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007513278,"about_ca_system_score_gemma":0.0007399191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006034977,"about_ca_topic_score_gemma":0.001957998,"domain_scores_codex":[0.9990786,0.0003539879,0.00008699868,0.0001487961,0.0002073555,0.0001242195],"domain_scores_gemma":[0.9988459,0.0002347672,0.0003707115,0.00008856206,0.0001659842,0.0002941033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4771251,0.01702801,0.04788247,0.001671466,0.004239279,0.0004439694,0.0002583057,0.002318822,0.02963241,0.0002728517,0.01119416,0.4079331],"study_design_scores_gemma":[0.3388903,0.3543821,0.2533229,0.0005152033,0.004760709,0.001766613,0.0003548046,0.00455405,0.009528818,0.0009066423,0.03079977,0.0002180163],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781479,0.009068214,0.0005492364,0.0005742419,0.0001171229,0.0008926016,0.005113827,0.00008764514,0.005449393],"genre_scores_gemma":[0.9883089,0.002175624,0.0007276124,0.0006876958,0.0001479679,0.0004437975,0.006085563,0.00001912725,0.001403644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002993038,"threshold_uncertainty_score":0.01001275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01894423835605781,"score_gpt":0.2816383504620555,"score_spread":0.2626941121059977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}